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PredProkDef SIGNED

Predicting of Prokaryotic Defence Distributions

Total Cost €

EC-Contrib. €

Partnership

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PredProkDef project word cloud

Explore the words cloud of the PredProkDef project. It provides you a very rough idea of what is the project "PredProkDef" about.

model place classes metagenomics uneven laboratories evolution pressure arsenal classified laboratory ecology industry biotechnology world structure bacteria types techniques expertise first discovered otago selfish defences genomics precision basic benefitting microbial disciplinary network defensive population spatial bioinformatic altruistic biology cutting zealand nutrient defence cycling interestingly edge health closely immunity exeter species uk individuals determinant return outgoing abortive variations independence suite phages me predicted infect constant mechanisms proximate understand classify combines abundance whereas viruses complement collaborative university sophisticated crispr healthcare background infection evade molecular class protects basis

Project "PredProkDef" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	272˙084 €
EC max contribution	272˙084 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-GF
Starting year	2020
Duration (year-month-day)	from 2020-02-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	coordinator	272˙084.00
2	UNIVERSITY OF OTAGO UNIVERSITY OF OTAGO Organization address address: SAINT DAVID STREET city: DUNEDIN postcode: 9054 website: www.otago.ac.nz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NZ (DUNEDIN)	partner	0.00

Map

Project objective

Bacteria are crucial for health, nutrient cycling and biotechnology but face a constant pressure from the viruses that infect them (phages). As such, bacteria have evolved a sophisticated suite of defence mechanisms that allow them to evade phages. These defence mechanisms can be classified into two basic classes: selfish or altruistic. A selfish system protects individuals, whereas an altruistic system protects the population. Interestingly, the distribution of this defensive arsenal is uneven, with large variations in the types carried, even among closely related species. This proposal aims to understand the basis of this distribution by using a multi-disciplinary approach that combines the precision of a model laboratory system with cutting-edge metagenomics techniques.

Specifically, I will use abortive infection as a model for altruistic defence and CRISPR as a model for selfish defence and test the role of spatial structure in determining the abundance of each type. High spatial structure is predicted to be a key determinant of altruistic defences as it results in proximate bacteria being closely related. I will then apply the findings from the first objectives to classify a novel, recently discovered, defence system. Together, these results will enable researchers to better understand microbial immunity, with key consequences for industry and healthcare.

The outgoing phase will take place at the University of Otago, New Zealand, using molecular biology expertise in abortive infection and CRISPR systems. The return phase will take place at the University of Exeter, UK, benefitting from expertise in ecology and evolution. The proposed project will allow me to complement my strong background in genomics and ecology with molecular biology and novel bioinformatic approaches. By working in two world-class research laboratories I will further develop independence and a strong collaborative network for the future.

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The information about "PREDPROKDEF" are provided by the European Opendata Portal: CORDIS opendata.