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X-MIXING SIGNED

Efficient mixing method at the microscale for Time-Resolved Serial Femtosecond Crystallography

Total Cost €

EC-Contrib. €

Partnership

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X-MIXING project word cloud

Explore the words cloud of the X-MIXING project. It provides you a very rough idea of what is the project "X-MIXING" about.

biology biochemical construction 1000 resolution 2005 x mixing elucidate free time faster started mechanism variation ph sensitive simulations horizons proof types femtosecond interdisciplinary 2017 22 investment electrohydrodynamic electron additionally configuration suitable nowadays limits limited microscale reactions scaling potentially generate methodology piv micro underlying paid efficient minimum substantially transfer crystallography reduce full xfel concerning conceiving embrace momentum serial induce lasers besides ray diffusion original critical union operation light temporal billion september jumps combination convection resolved explore shown structural dynamic germany advantage numerical experiments temperature physical scales spatiotemporal versatility

Project "X-MIXING" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SEVILLA Organization address address: CALLE S. FERNANDO 4 city: SEVILLA postcode: 41004 website: www.us.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	197˙529 €
EC max contribution	197˙529 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-GF
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SEVILLA UNIVERSIDAD DE SEVILLA Organization address address: CALLE S. FERNANDO 4 city: SEVILLA postcode: 41004 website: www.us.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SEVILLA)	coordinator	197˙529.00
2	TRUSTEES OF PRINCETON UNIVERSITY TRUSTEES OF PRINCETON UNIVERSITY Organization address address: NASSAU HALL 1 city: PRINCETON, NJ postcode: 08544-2001 website: http://www.princeton.edu/main/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PRINCETON, NJ)	partner	0.00

Map

Project objective

X-MIXING is an interdisciplinary project aimed at conceiving an efficient mixing method at the microscale suitable for triggering not-light sensitive biochemical reactions in the application of Time-Resolved Serial Femtosecond Crystallography. Nowadays, the temporal resolution of this type of dynamic structural biology analysis with X-ray Free-Electron Lasers is limited by the minimum mixing time that current methods can produce. As it is shown in a proof-of-concept, an exciting combination of electrohydrodynamic fields and momentum transfer lead to a significant variation of the spatiotemporal scales within the convection-diffusion mechanism. So, this configuration can potentially generate mixing from 100 to 1000 faster than current means do. Besides, its versatility would enable not only to reduce the mixing time substantially, but also to induce jumps in PH and temperature that would additionally open horizons concerning new types of triggering reactions in the field. These critical features have the potential to become this original configuration in a key to take full advantage of the recent significant investment, over 1,22 billion euro (2005 value), paid by European Union and partners for the construction of the European XFEL (Germany), whose user operation started in September 2017. To explore and elucidate the underlying physical limits of the proposed method, the research methodology of this project will embrace different approaches such as micro-PIV experiments, numerical simulations, and scaling analysis.

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The information about "X-MIXING" are provided by the European Opendata Portal: CORDIS opendata.