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DECOMPACT SIGNED

Development of Collagenase Polymeric nanocapsules as Therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

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 DECOMPACT project word cloud

Explore the words cloud of the DECOMPACT project. It provides you a very rough idea of what is the project "DECOMPACT" about.

digest    matrices    form    grant    nanocapsules    model    vivo    trigger    incidence    social    considering    combine    place    market    treatment    protect    situ    team    scleroderma    fibers    mouse    linkers    immunosuppressive    digestion    evaluation    stimuli    skin    compromises    housed    anti    sensitive    adg    supposes    capacity    verdi    treatments    fibrotic    abnormal    conventional    induce    professionals    expert    proof    uva    commercialization    medical    methodology    library    obtain    degrade    society    exposition    responsive    irradiation    economic    plan    embraces    external    collagenase    enzyme    population    cells    vitro    2015    erc    3d    cross    innovation    insults    synthesis    694160    diseases    doctors    immunosuppressant    human    nature    labile    employing    context    body    enzymes    respect    polymeric    decompact    nanodevices    collagen    specialized    proteolytic    release    nanodevice    inflammatory    benefits    disease    nanotechnology    purposes    therapeutics    accumulation   

Project "DECOMPACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙611 €
 EC max contribution 149˙611 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 149˙611.00

Map

 Project objective

“Developments of Collagenase Polymeric nanocapsules as Therapeutics (DECOMPACT)”. The goal of this proof of concept project is the development and commercialization of a novel treatment to scleroderma. Scleroderma is a fibrotic disease with a significant incidence in the population and is characterized by an abnormal accumulation of collagen. Treatment of this disease involves the use of proteolytic enzymes, as collagenase, able to digest collagen fibers. However, the labile nature of collagenase compromises its activity in the human body. DECOMPACT purposes the development of polymeric-collagenase nanocapsules that protect the housed enzymes against external insults and are able to release them by UVA irradiation exposition. UVA irradiation has been selected as trigger release stimuli due to its capacity to induce both anti-inflammatory, immunosuppressive effects and to enhance collagenase production in situ. These novel stimuli-responsive nanodevices would combine the ability of the proteolytic enzyme to degrade collagen with the immunosuppressant and anti-inflammatory effects of UVA. The methodology to obtain the system is based on previous results achieved in the context of the Advance Grant ERC-2015-AdG Proposal No.694160, VERDI. The work plan involves the synthesis of a library of UVA-sensitive cross-linkers which form the nanodevice, studies of UVA-responsive and evaluation of collagen digestion ability both in vitro employing 3D collagen matrices with skin cells embedded and in vivo using a scleroderma mouse model. This project supposes an important innovation respect to conventional treatments and could provide important social-economic benefits to the society. Finally, DECOMPACT embraces a work plan considering the commercialization steps which are required in order to place this technology in the market. The work team involved in this project includes specialized professionals in nanotechnology and medical doctors expert in fibrotic diseases.

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The information about "DECOMPACT" are provided by the European Opendata Portal: CORDIS opendata.

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