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BioPhoCS SIGNED

Bio- & Photo-Catalytic Methods for the Construction of Enantiomerically Pure C-S Bonds in Thiols and Sulphides

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioPhoCS project word cloud

Explore the words cloud of the BioPhoCS project. It provides you a very rough idea of what is the project "BioPhoCS" about.

view    light    lack    biocatalyse    cascade    chemistry    ingredients    biocatalytic    natural    pharmaceutical    configurations    centres    pot    olfactory    reductase    sustainable    ubiquitous    successful    bonds    situ    volatile    substrates    catalysis    organic    prepare    chiral    ligands    tools    blue    fine    thiols    verticillins    asymmetrical    biocatalysis    catalysts    industries    photocatalysis    chemical    adh    photocatalytic    excipients    mechanisms    enantiomerically    thioketones    chemicals    sulphides    enantiopure    intriguing    determined    photo    construction    green    strategies    will    synthesis    kinetic    odorous    containing    nmr    manufacturing    stereoselective    conferred    flavours    construct    pure    chemists    classes    combination    penicillins    flavouring    reactions    designed    facile    sulphur    thioalkenes    kred    efficient    bio    enantioselective    fragrances    agrochemicals    enzymes    compounds    ered    peculiar    absolute    reaction    assembling   

Project "BioPhoCS" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 224˙933.00

Map

 Project objective

Organic sulphur compounds containing C-S chiral centres represent one of the most intriguing classes of chemicals due to their peculiar properties conferred by the unique chemistry of sulphur. Chiral sulphur compounds are known for their olfactory properties as flavours and fragrances and are ubiquitous in natural products and pharmaceutical ingredients such as penicillins and verticillins. Both the flavouring and pharmaceutical properties of chiral sulphur compounds are often determined by their absolute configurations. Therefore, the development of novel, robust and sustainable methods for the enantioselective construction of C-S bonds is of great importance in chemistry. In view of the lack of efficient and stereoselective methods in assembling asymmetrical C-S bonds, within this project we aim to construct enantiopure sulphur compounds through photo- and bio-catalysis. Various strategies have been designed to achieve this target, exploiting blue/green light photocatalysis and biocatalysis by reductase enzymes such as KRED, ADH and ERED. The ability of these enzymes to biocatalyse the enantioselective reduction of thioketones and thioalkenes obtained via photocatalysis, will be investigated. In addition, the combination of photocatalytic synthesis of substrates with the biocatalytic construction of enantiomerically pure C-S bonds in one-pot cascade processes will be developed. These methods will be finally applied to the synthesis of chiral volatile sulphur compounds as odorous excipients, while in-situ NMR kinetic studies of the photo-biocatalytic reactions will be carried out to get a better understanding of the reaction mechanisms. The successful development of these strategies will allow chemists and industries to access facile and sustainable approaches to prepare a wide range of challenging chiral thiols and sulphides to be used in the manufacturing of pharmaceutical ingredients, fine chemical tools (ligands, catalysts), agrochemicals and fragrances.

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