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SEAROX SIGNED

Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles

Total Cost €

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EC-Contrib. €

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Partnership

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 SEAROX project word cloud

Explore the words cloud of the SEAROX project. It provides you a very rough idea of what is the project "SEAROX" about.

annulations    unprecedented    preparation    regioselectivity    discovery    scaffold    gold    diversifiable    donor    directing    heterocycle    preparations    economy    emerged    host    nitrogen    er    species    reducing    davies    enhanced    nucleophilic    group    patterns    limits    motifs    substitution    nitrenoids    readily    influence    utility    rd    translates    base    complementary    pioneer    optimal    probe    phenotypic    libraries    screening    drug    reactions    accessible    active    industrial    skills    metal    alkynes    reaction    sulfur    paul    sustainability    chemical    selectivity    demand    molecule    pharmaceutical    coupling    ps    stage    biologically    intermolecular    reactivity    impart    science    energy    dr    prakash    library    reactants    groups    agrochemical    expertise    catalysed    broad    benefits    equip    modular    space    diverse    industries    catalysis    practically    establishing    oxazoles    vital    academic    structurally    activated    ubiquitous    sekar    integrate    functional    combinations    cross    heterocycles    searox    efficient   

Project "SEAROX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial RD. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

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