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SEAROX SIGNED

Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles

Total Cost €

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EC-Contrib. €

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Partnership

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 SEAROX project word cloud

Explore the words cloud of the SEAROX project. It provides you a very rough idea of what is the project "SEAROX" about.

science    intermolecular    searox    reaction    ps    economy    paul    pharmaceutical    heterocycles    base    efficient    coupling    optimal    accessible    equip    sekar    chemical    unprecedented    rd    dr    readily    heterocycle    stage    cross    nitrogen    sulfur    broad    establishing    functional    enhanced    preparations    space    diverse    pioneer    impart    alkynes    scaffold    davies    benefits    drug    limits    reactions    metal    nucleophilic    screening    selectivity    vital    preparation    patterns    reactivity    agrochemical    discovery    oxazoles    diversifiable    molecule    prakash    reducing    library    catalysed    modular    translates    species    phenotypic    probe    industrial    reactants    industries    sustainability    structurally    active    catalysis    expertise    gold    directing    libraries    donor    practically    energy    demand    integrate    influence    academic    group    utility    groups    ubiquitous    annulations    complementary    substitution    emerged    er    nitrenoids    skills    activated    host    combinations    motifs    regioselectivity    biologically   

Project "SEAROX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial RD. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

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