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SEAROX SIGNED

Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles

Total Cost €

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EC-Contrib. €

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Partnership

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 SEAROX project word cloud

Explore the words cloud of the SEAROX project. It provides you a very rough idea of what is the project "SEAROX" about.

pioneer    emerged    sekar    nitrogen    benefits    stage    economy    substitution    directing    translates    coupling    active    paul    reactants    sustainability    broad    intermolecular    energy    gold    agrochemical    activated    groups    species    er    regioselectivity    practically    biologically    group    limits    prakash    impart    skills    donor    alkynes    oxazoles    optimal    enhanced    base    functional    heterocycle    catalysed    drug    dr    diverse    host    combinations    modular    ps    sulfur    preparations    nucleophilic    establishing    patterns    science    unprecedented    annulations    ubiquitous    utility    library    structurally    libraries    probe    rd    industrial    screening    chemical    expertise    molecule    equip    reducing    pharmaceutical    selectivity    readily    metal    complementary    demand    accessible    scaffold    catalysis    industries    reactivity    academic    heterocycles    efficient    phenotypic    cross    influence    diversifiable    reaction    integrate    motifs    searox    vital    space    davies    nitrenoids    reactions    preparation    discovery   

Project "SEAROX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial RD. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

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The information about "SEAROX" are provided by the European Opendata Portal: CORDIS opendata.

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