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IA-NANO SIGNED

Albumin particles for intra-articular delivery of celecoxib to treat osteoarthritic inflammation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IA-NANO project word cloud

Explore the words cloud of the IA-NANO project. It provides you a very rough idea of what is the project "IA-NANO" about.

cyclooxygenase    fourth    injections    anti    host    repeated    topical    synoviocytes    loaded    concentration    outcomes    free    osteoarthritis    curable    suboptimal    2020    shortcomings    option    rat    mechanism    world    biodegradable    local    joints    symptomatic    commercial    prescribed    model    human    medications    biocompatible    un    line    particles    inject    employability    hyaluronic    molecules    administration    albumin    gain    articular    knee    demographic    societal    benefit    space    oa    translational    joint    health    steroidal    toxic    celecoxib    therapy    oral    horizon    acid    injected    area    position    ia    screening    predicted    though    reduce    primary    corticosteroids    acting    clearance    bioassay    rapid    efficacy    wellbeing    edge    inflammatory    inhibitor    drug    chronic    deciphered    candidate    biomarkers    ddss    sustainable    release    load    vitro    complete    experts    good    disability    pharmaceutics    inflamed    source    researcher    supervisors    cutting   

Project "IA-NANO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

Osteoarthritis (OA) is the most common chronic condition of the joints and is predicted to become the fourth largest cause of disability in the world by 2020. Its complete mechanism is yet to be deciphered. Though it is not curable, several medications are prescribed to manage the symptomatic OA, of which the oral and topical medications have shortcomings and the better option is the intra-articular (IA) delivery of free corticosteroids and hyaluronic acid. However, IA delivery is challenging due to the rapid clearance of the free injected molecules from the joint space and outcomes are suboptimal in terms of efficacy and a need for repeated injections. Our objective therefore is to load a candidate drug in a long-acting delivery system and inject it directly into the inflamed knee of a rat model of OA, following in vitro bioassay screening in primary human synoviocytes. Thus, in this project, we propose to develop non-toxic, biocompatible and biodegradable albumin particles loaded with the non-steroidal anti-inflammatory cyclooxygenase-2 inhibitor, celecoxib. This method is expected to reduce the side-effects associated with oral administration of celecoxib. In addition, it will also increase the drug local concentration in the joint and the controlled release of the drug will lead to reduction of inflammatory biomarkers in joints. The project is in line with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development goal - Good Health and Well-Being. It will be carried out by the researcher and supervisors who are experts in DDSs development, OA therapy and translational pharmaceutics. Both the researcher and the host are expected to benefit in this collaboration and the researcher will gain experience that will increase her future employability. The project will have great societal impact and commercial potential and will also help increase Europe’s position as the leading source of cutting-edge research.

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The information about "IA-NANO" are provided by the European Opendata Portal: CORDIS opendata.

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