Opendata, web and dolomites

IA-NANO SIGNED

Albumin particles for intra-articular delivery of celecoxib to treat osteoarthritic inflammation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IA-NANO project word cloud

Explore the words cloud of the IA-NANO project. It provides you a very rough idea of what is the project "IA-NANO" about.

translational    human    host    sustainable    researcher    repeated    primary    benefit    acid    medications    rapid    drug    mechanism    biomarkers    wellbeing    complete    option    societal    injections    rat    employability    deciphered    corticosteroids    shortcomings    therapy    cutting    clearance    osteoarthritis    joints    local    health    albumin    supervisors    oral    though    oa    prescribed    un    inject    demographic    area    inflammatory    chronic    candidate    cyclooxygenase    experts    inhibitor    topical    gain    injected    pharmaceutics    fourth    edge    2020    knee    inflamed    source    outcomes    vitro    model    acting    synoviocytes    ia    particles    steroidal    concentration    molecules    administration    world    symptomatic    efficacy    articular    loaded    load    position    bioassay    commercial    space    anti    celecoxib    line    biodegradable    predicted    suboptimal    hyaluronic    toxic    horizon    biocompatible    reduce    joint    curable    disability    good    screening    free    release    ddss   

Project "IA-NANO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

Osteoarthritis (OA) is the most common chronic condition of the joints and is predicted to become the fourth largest cause of disability in the world by 2020. Its complete mechanism is yet to be deciphered. Though it is not curable, several medications are prescribed to manage the symptomatic OA, of which the oral and topical medications have shortcomings and the better option is the intra-articular (IA) delivery of free corticosteroids and hyaluronic acid. However, IA delivery is challenging due to the rapid clearance of the free injected molecules from the joint space and outcomes are suboptimal in terms of efficacy and a need for repeated injections. Our objective therefore is to load a candidate drug in a long-acting delivery system and inject it directly into the inflamed knee of a rat model of OA, following in vitro bioassay screening in primary human synoviocytes. Thus, in this project, we propose to develop non-toxic, biocompatible and biodegradable albumin particles loaded with the non-steroidal anti-inflammatory cyclooxygenase-2 inhibitor, celecoxib. This method is expected to reduce the side-effects associated with oral administration of celecoxib. In addition, it will also increase the drug local concentration in the joint and the controlled release of the drug will lead to reduction of inflammatory biomarkers in joints. The project is in line with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development goal - Good Health and Well-Being. It will be carried out by the researcher and supervisors who are experts in DDSs development, OA therapy and translational pharmaceutics. Both the researcher and the host are expected to benefit in this collaboration and the researcher will gain experience that will increase her future employability. The project will have great societal impact and commercial potential and will also help increase Europe’s position as the leading source of cutting-edge research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IA-NANO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IA-NANO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

Magik Star (2019)

MAGnetic fIeld and Kinematic coupling for massive STAR formation

Read More