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SingCelCD SIGNED

Single Cell approaches for the study of oncogenic processes during coeliac disease.

Total Cost €

EC-Contrib. €

Partnership

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SingCelCD project word cloud

Explore the words cloud of the SingCelCD project. It provides you a very rough idea of what is the project "SingCelCD" about.

functional cells notably training autoimmune extend usually cell single gain therapeutic enteropathy jak1 put edge strategies demonstrated dietary clonal lymphomas human position chronic search lymphoproliferation opportunity tumor malignant rare stepping advantage host europeans expertise diseases center me translational microenvironment reinforce leader stone cutting rcdii intraepithelial disease progression complicating heterogeneity immunology complication bioinformatics patients cd excellent preceded genetics stat3 onset inhibitors refractory genetic approximately mechanisms peri technologies pertinent gluten laboratory 2 independent cellular 70 researcher tumoral giving anti intend invasive collaborations complete integrate coeliac pathophysiology genomic innovative checkpoint grade

Project "SingCelCD" data sheet

The following table provides information about the project.

Coordinator	IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION Organization address address: 24 BD DU MONTPARNASSE city: PARIS 15 postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	196˙707 €
EC max contribution	196˙707 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-RI
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION Organization address address: 24 BD DU MONTPARNASSE city: PARIS 15 postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	coordinator	196˙707.00

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Project objective

Coeliac disease is a chronic autoimmune-like enteropathy induced by dietary gluten in 0.5-2% Europeans. A rare but specific complication is the onset of invasive enteropathy-associated lymphomas. The host laboratory has demonstrated that in approximately 70% of CD patients, invasive lymphomas are preceded by a clonal low-grade intraepithelial lymphoproliferation, usually called type II refractory CD (RCDII). I intend to take advantage of my experience in cellular immunology and single-cell analyses: 1- to analyse the peri-tumor microenvironment and search for anti-tumoral T cell response in RCDII; and 2- to analyse the functional intra-clonal heterogeneity among RCDII malignant cells. The results should provide further insight into the mechanisms, which control disease progression and will help us to assess therapeutic strategies. This project will complete and extend the on-going genomic analysis of lymphomas complicating CD. It will notably help to assess if the JAK1/STAT3 pathway is a pertinent therapeutic target and the possible interest of checkpoint inhibitors. To achieve the aims of the innovative translational project, I will integrate one of the European leader research center in genetic diseases, giving me the opportunity to gain experience in translational immunology and human genetics, as well as to reinforce my expertise in cutting-edge single cell technologies and bioinformatics. Overall this project represents a unique stepping-stone to complete my training in pathophysiology and establish collaborations, which should put me in excellent position to establish as an independent researcher.

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The information about "SINGCELCD" are provided by the European Opendata Portal: CORDIS opendata.