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THyM SIGNED

Why is Transparent Hypocotyl Mutant showed reduced phototropic response?

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 THyM project word cloud

Explore the words cloud of the THyM project. It provides you a very rough idea of what is the project "THyM" about.

auxin    atabc    hypotheses    mutant    biochemical    cassette    rapa    characterization    hypocotyl    initiated    blue    fiber    plant    play    photo    transport    vision    lab    defect    optic    shares    transported    atp    eye    tagged    family    confocal    wild    underlies    protein    functional    understand    showed    gradients    levels    photosynthesis    photosensory    drosophila    primary    first    reorient    perceiving    techniques    trigger    organ    plants    wall    transporter    visualize    orthologous    signaling    testable    cellular    brasicca    phenotypic    function    abc    pigment    vital    hypocotyls    activated    transporters    insect    homology    components    phototropism    precursor    gfp    proteins    phenotype    microscopy    favorable    receptors    cell    stem    binding    establishment    microscopic    gradient    insights    downstream    fankhauser    subcellular    localization    transparent    pattern    tissue    light    gene    optimize    expression    defective    staining    asymmetric    environment    phototropin    substance    conservation    stimulated    mutants    regarding   

Project "THyM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00

Map

 Project objective

Plants can reorient their growth towards a favorable light environment to optimize photosynthesis in a process called phototropism. This process is initiated by the phototropin blue light receptors, perceiving light gradients to trigger downstream signaling leading to the asymmetric distribution of auxin across the photo-stimulated stem. The Fankhauser lab showed that AtABC, an ABC (ATP-binding cassette) transporter family protein is important for phototropism. AtABC shares homology with Drosophila transporters, which are involved in eye pigment precursor transport and play a vital role in insect vision. In addition to reduced phototropism, Atabc mutants have transparent hypocotyls. The primary objective of this project is to understand the function of AtABC in phototropism and to test whether this transporter is required for light gradient establishment across the hypocotyl. First, I will characterize the Atabc mutant at the tissue, cellular and subcellular levels (e.g. staining for cell wall components) to determine what defect underlies the transparent hypocotyl phenotype. Using several approaches including confocal microscopy to visualize light-activated proteins and fiber-optic techniques, I will measure the light gradient across the hypocotyl of wild type and Atabc mutants. I will characterize phototropin signaling using biochemical and microscopic approaches to determine at which signaling step AtABC is required. To characterize AtABC, I will determine its expression pattern and subcellular localization using GFP-tagged AtABC. Together with the phenotypic characterization of the mutant, this will provide testable hypotheses regarding the substance(s) transported by AtABC. Finally, to determine the functional conservation of AtABC in other plants, I will characterize Brasicca rapa mutants defective in the orthologous gene. The functional characterization of AtABC may provide key insights into light gradient establishment in a plant photosensory organ.

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The information about "THYM" are provided by the European Opendata Portal: CORDIS opendata.

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