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GUTPOLAR SIGNED

Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GUTPOLAR project word cloud

Explore the words cloud of the GUTPOLAR project. It provides you a very rough idea of what is the project "GUTPOLAR" about.

structural    acidification    secondment    interactions    evolutionary    community    link    first    despite    mammals    he    controls    reinforce    myo5b    organelle    function    diseases    disease    array    brush    interestingly    relies    researcher    sustainably    rare    apical    absorption    luminal    imaging    intestinal    uncovered    mutations    reintegrating    pole    mammalian    organoids    lab    genetics    bb    mechanism    physical    cells    conservation    mispolarized    phenotypes    traffic    farin    acquire    disorders    resolution    maintenance    inclusion    mvid    forming    proteins    mouse    trafficking    describe    coding    thanks    atpase    medical    border    super    v0    food    therapeutic    recapitulates    malabsorption    microvillus    microvilli    genes    modules    depletion    skills    frankfurt    epithelial    polarity    vivo    candidate    gutpolar    genetic    cellular    par    mechanisms    routes    germany    er    intestine    model    elegans    action    patients    conserved    molecular    membrane    components    little    caused    functional   

Project "GUTPOLAR" data sheet

The following table provides information about the project.

Coordinator		 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-06   to  2021-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

The GUTPOLAR project aims at sustainably reintegrating an Experience Researcher (ER) who will acquire the necessary knowledge and skills to reinforce European research on rare malabsorption diseases. Food absorption relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border (BB) at their luminal (apical) pole. Some rare genetic malabsorption disorders, characterized by mispolarized PAR polarity modules and BB structural proteins, are caused by mutations in genes coding for membrane traffic factors (i.e. Myo5B in microvillus inclusion disease/MVID). Despite this functional link, little is known about the genetic, physical and functional interactions between membrane traffic, polarity and BB components in vivo and how they control intestinal absorption. The ER uncovered a new role of the V0 sector of the V-ATPase, a complex that controls membrane traffic through organelle acidification, in both polarity and BB components apical polarity maintenance in C. elegans intestine. Most interestingly, V0-ATPase depletion in C. elegans recapitulates the cellular phenotypes observed in patients with MVID, making this complex a very exciting candidate which mechanism, genetic partners and mammalian function need to be characterized. To this end, the ER will first use genetics and super-resolution imaging to study the trafficking routes and the molecular mechanisms controlled by the V0-ATPase in vivo in C. elegans intestine. Then, he will implement mouse intestinal organoids (thanks to a secondment in H. Farin’s lab, Frankfurt, Germany) and use this model to study the conservation of these mechanisms in mammals. Overall, the GUTPOLAR action will allow to describe evolutionary conserved pathways of polarity maintenance and identify some of the mechanisms leading to absorption disorders that may provide the medical community with new therapeutic targets.

 Publications

year authors and title journal last update
List of publications.
2019 Aurélien Bidaud-Meynard, Ophélie Nicolle, Markus Heck, Yann Le Cunff, Grégoire Michaux
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
published pages: dev174508, ISSN: 0950-1991, DOI: 10.1242/dev.174508 		Development 146/11 2019-07-22

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