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BREEDIT SIGNED

A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE

Total Cost €

EC-Contrib. €

Partnership

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BREEDIT project word cloud

Explore the words cloud of the BREEDIT project. It provides you a very rough idea of what is the project "BREEDIT" about.

crossings yielding evaluation regulatory breed pace cas9 yield alleles threats unprecedented subsequent security biology climate evaluations too nature editing combinatorial stacked word food house mutations programs complexity entire mediated gene characterised sequencing follow genetic networks phenotypic platform frequency poses erc elite expeditious crop schemes efficiency optimal molecular reflects underlying plant plants provoke material implementing integrating varieties feeding introducing phenotypes multiplex unifying shift rounds basic world beneficial breeding crossing phenotyping combining edits agriculture amplicon collection image gain combinations basis imminent scheme changing edited genome genes centric effect proposes automated breedit crispr global paradigm population acronym fusion

Project "BREEDIT" data sheet

The following table provides information about the project.

Coordinator	VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	2˙474˙790 €
EC max contribution	2˙474˙790 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-ADG
Funding Scheme	ERC-ADG
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2024-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VIB VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	coordinator	2˙474˙790.00

Map

Project objective

Feeding the growing world population under changing climate conditions poses an unprecedented challenge on global agriculture and our current pace to breed new high yielding crop varieties is too low to face the imminent threats on food security. This ERC project proposes a novel crossing scheme that allows for an expeditious evaluation of combinations of potential yield contributing alleles by unifying ‘classical’ breeding with gene-centric molecular biology. The acronym BREEDIT, a word fusion of breeding and editing, reflects the basic concept of combining breeding with multiplex genome editing of yield related genes. By introducing plants with distinct combinations of genome edited mutations in more than 80 known yield related genes into a crossing scheme, the combinatorial effect of these mutations on plant growth and yield will be evaluated. Subsequent rounds of crossings will increase the number of stacked gene-edits per plant, thus increasing the combinatorial complexity. Phenotypic evaluations throughout plant development will be done on our in-house automated image-analysis based phenotyping platform. The nature and frequency of Cas9-mediated mutations in the entire plant collection will be characterised by multiplex amplicon sequencing to follow the efficiency of CRISPR-cas9 genome editing and to identify the underlying combinations of genes that cause beneficial phenotypes (genetic gain). The obtained knowledge on yield regulatory networks can be directly implemented into current molecular breeding programs and the project will provide the basis to develop targeted breeding schemes implementing the optimal combinations of beneficial alleles into elite material. BREEDIT will be a major step forward in integrating basic knowledge on genes with plant breeding and has the potential to provoke a paradigm shift in improving crop yield.

Deliverables

List of deliverables.
Participation in the Open Research Data Pilot	Open Research Data Pilot	2020-03-11 14:45:33

Take a look to the deliverables list in detail: detailed list of BREEDIT deliverables.

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The information about "BREEDIT" are provided by the European Opendata Portal: CORDIS opendata.