Opendata, web and dolomites

MICROX SIGNED

Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MICROX project word cloud

Explore the words cloud of the MICROX project. It provides you a very rough idea of what is the project "MICROX" about.

atmospheric    mazina    dramatically    sensitivity    discovering    monitoring    group    candidates    academic       maintaining    temporal    content    dr    fluorescent    assays    combination    never    cancer    cells    platform    tested    prof    screening    trivial    luminescence    bioactive    drug    microscopes    validated    generally    fluorescence    private    olga    incubators    facilities    regimens    close    panel    function    exquisite    solid    bodies    probe    plate    functional    cell    world    lt    oxygen    team    events    innovative    remarkably    spatial    dynamic    societies    evaluation    conventional    preparation    jalink    microx    hypoxic    optimized    tight    pharmacologist    21    adjustable    treatment    efficacy    signalling    o2    biochemist    urgent    levels    optical    hi    microscopy    enclose    compounds    outperform    drugs    medical    complement    good    reader    biosensors    manufacturers    kees    resolution    tumours    oxygenation       treatments    modern    maintained    living    evident    hypoxia   

Project "MICROX" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 281˙358 €
 EC max contribution 281˙358 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2022-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 281˙358.00

Map

 Project objective

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

FarGo (2019)

'Farming God's Way': Cultivation and religious practice in contemporary South Africa

Read More