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LEECHSYMBIO SIGNED

The Mexican leech Haementeria officinalis and its nutritional symbiont as a model system for the study of strict blood-feeding animal-microbe symbioses and bacteriocyte development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LEECHSYMBIO project word cloud

Explore the words cloud of the LEECHSYMBIO project. It provides you a very rough idea of what is the project "LEECHSYMBIO" about.

genome    metabolic    experimental    determined    feeding    rely    imaging    background    bioinformatics    medically    species    houses    sequence    helobdella    mexican    confronted    organ    showed    techniques    symbioses    specialised    providencia    complementarity    analysed    supplement    additional    genomic    isotope    transfer    symbionts    identification    acquisition    ensures    metabolomics    chemical    molecular    maintained    genes    determinants    leech    insights    model    evolution    bacterial    officinalis    blood    microbe    sequenced    intricacies    animals    deficiency    genomes    developmental    ideal    unbalanced    colonization    history    reconstruct    strict    host    researcher    bacteriome    symbiosis    evolutionary    microscopy    lab    core    probing    intracellular    habit    interactions    biosynthesis    siddallii    robusta    diet    organs    leeches    experiments    independent    haementeria    efficient    symbiont    nutritional    truly    environment    stages    vitamin    postdoc   

Project "LEECHSYMBIO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-15   to  2022-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 186˙167.00

Map

 Project objective

Strict blood-feeding leeches are confronted with a strong B-vitamin deficiency and thus rely on bacterial symbionts to supplement their unbalanced diet. Recent evidence showed that the Mexican leech Haementeria officinalis houses in a distinct specialised organ intracellular Providencia siddallii symbionts, which have a highly reduced genome but maintained genes required for B vitamin biosynthesis. The aim of this proposal is to establish this leech as a model system for studying the intricacies of nutritional blood-feeding symbioses. The genomes of Providencia symbionts of 4 additional Haementeria species will be sequenced and analysed to identify core-metabolic pathways and to reconstruct the evolutionary history of this symbiosis. A draft genome sequence of the Mexican leech Ha. officinalis will be determined, providing unique insights into metabolic complementarity. Comparison with the available genome of the related non-blood-feeding leech Helobdella robusta will facilitate identification of genomic determinants of the acquisition/loss of the bacteriome and the blood feeding habit. Bacteriome development and colonization will be investigated using different developmental stages and advanced microscopy techniques. Host control and nutritional role of the symbiont will be studied using isotope probing experiments and state-of-the-art chemical imaging and metabolomics methods. This project will provide comprehensive insights into a nutritional symbiosis in medically relevant blood-feeding animals, including the evolution of specialised symbiosis organs and metabolic interactions between both partners. It will bring together a postdoc with a strong background in bioinformatics and bacterial symbionts with a host lab focused on experimental and molecular analysis of microbe-host interactions. This set-up ensures both an ideal environment for the postdoc on his way to an truly independent researcher, and an efficient two-way transfer of knowledge.

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The information about "LEECHSYMBIO" are provided by the European Opendata Portal: CORDIS opendata.

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