Opendata, web and dolomites

THIAZOLIUMenzyme SIGNED

Enzyme design and engineering by implementation of non-canonical amino acids in protein scaffolds

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THIAZOLIUMenzyme project word cloud

Explore the words cloud of the THIAZOLIUMenzyme project. It provides you a very rough idea of what is the project "THIAZOLIUMenzyme" about.

reactions    enzymes    cells    engineering    mediated    convey    organocatalytic    building    perform    genetic    expansion    pave    extend    overcome    revolutionise    generally    drawbacks    nhc    serving    catalyse    anticipated    bioorthogonal    catalysts    small    evolvable    purposes    clinical    synthesis    biocatalysts    industry    aldolase    blocks    box    organocatalysed    efficient    code    de    incorporating    abiological    engineered    therapeutics    portfolio    strategies    tool    promiscuous    enzyme    chemistry    attractive    un    transformations    enzymology    natural    heterocyclic    site    biology    novo    retro    artificial    molecule    loading    conventionally    desired    acids    ra95    greener    environmentally    temperature    carbene    reprogramming    limits    uses    industrial    medicine    biocatalytic    alternative    protein    enzymatic    catalyst    cell    options    orchestrating    thiazolium    active    nature    amino    medicinal    proteins   

Project "THIAZOLIUMenzyme" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2021-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 191˙149.00

Map

 Project objective

The design of enzymatic catalysts and protein therapeutics with tailored, new-to-nature properties is a long-standing goal in enzymology and cell biology. Nature generally uses 20 amino acids as building blocks for protein synthesis. However, this portfolio limits the options for engineering proteins with ‘un-natural’ activities. Recent developments in the expansion of the genetic code have the potential to revolutionise the design of novel enzymes; by reprogramming the genetic code, we could convey novel functionality into proteins and extend their properties. This project aims at incorporating thiazolium amino acids into the active site of a promiscuous and highly evolvable de novo enzyme, namely the RA95 (retro)-aldolase, for orchestrating organocatalytic transformations of clinical and industrial interest. Such reactions, conventionally mediated by non-enzymatic, small molecule N-heterocyclic carbene (NHC) catalysts require high temperature and catalyst loading. An engineered enzyme with the ability to catalyse such chemistry may overcome the drawbacks of these abiological catalysts, serving as a ‘greener’ biocatalytic alternative, and also perform the desired reactions in cells for medicinal purposes. This initiative will pave the way for development of general strategies for creating enzymes with unique properties and provide a tool-box for efficient, environmentally-friendly and bioorthogonal organocatalysed reactions. It is anticipated that the generated artificial biocatalysts will have attractive applications in research, medicine and industry.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THIAZOLIUMENZYME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THIAZOLIUMENZYME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

LYSOKIN (2020)

Architecture and regulation of PI3KC2β lipid kinase complex for nutrient signaling at the lysosome

Read More  

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

SpaTime_AnTB (2020)

Single-cell spatiotemporal analysis of Mycobacterium tuberculosis responses to antibiotics within host microenvironments

Read More