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SchiSTOP SIGNED

Beyond mass drug administration: understanding Schistosomiasis dynamics to STOP transmission

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SchiSTOP project word cloud

Explore the words cloud of the SchiSTOP project. It provides you a very rough idea of what is the project "SchiSTOP" about.

vlas    heavy    intensive    organization    americas    stochastic    insights    reduce    health    world    mc    erasmus    drug    infectious    transmission    de    administration    mathematical    africa    people    sake    subtropical    prof    aged    region    statistical    optimal    priorities    immunology    proven    rapid    mda    deadliest    le    killing    global    framework    poppy    secondment    ways    model    epidemiology    asia    move    strategies    dynamics    proposing    glasgow    prevalent    mechanisms    lamberton    integrating    individual    ibm    dr    rebound    cutting    ntds    children    elimination    populations    poorly    genetics    met    tropical    gain    schistosomiasis    diseases    simulate    neglected    2020    edge    university    sdg    280    models    diagnostics    comprehensively    african    parasite    poverty    intensity    infections    reference    methodological    mass       round    underlying    prevalence    diverse    school    biannual    ntd    unlikely    group    income    moderate    seems    alone   

Project "SchiSTOP" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 175˙572.00

Map

 Project objective

Neglected tropical diseases (NTDs) are a diverse group of infections which are especially prevalent in low-income populations in tropical and subtropical areas in Africa, Asia and the Americas. Schistosomiasis is the deadliest NTD killing an estimated 280,000 people each year in the African region alone. The World Health Organization (WHO) 2020 target for schistosomiasis is to reduce the prevalence of heavy-intensity infections to ≤5% among school-aged children through Mass Drug Administration (MDA). However, in areas of moderate and high prevalence the goal seems unlikely to be met as even with intensive biannual MDA, prevalence of infections are still seen to rebound rapidly after each round. The reasons are still poorly understood. Mathematical models and statistical methods have proven to be essential to gain insights into the complex processes underlying the transmission dynamics of infectious diseases. In this research project, I will develop a stochastic individual-based model (IBM) to simulate schistosomiasis transmission integrating cutting-edge mathematical models and statistical methods with recent advances in parasite genetics, epidemiology, diagnostics and immunology. This project aims to advance our current understanding of schistosomiasis transmission dynamics investigating the mechanisms that cause the rapid rebound of prevalence after MDA and proposing optimal implementation of current and novel strategies to achieve schistosomiasis control and move towards elimination. In addition, this project will build a reference methodological framework to comprehensively study other MDA targeted infectious diseases. The proposed project addresses one of the priorities of the EU, through global poverty reduction (SDG goal 1) by promoting ways of improving future health (SDG goal 3).This project will be carried out at Erasmus MC with Prof. Sake J. de Vlas and at University of Glasgow (secondment) with Dr. Poppy Lamberton.

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