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Monopoly SIGNED

Baeyer Villiger Monooxygenases as Biocatalytic Parts for Monomers of New Lactone-based Polymeric Materials

Total Cost €

EC-Contrib. €

Partnership

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Monopoly project word cloud

Explore the words cloud of the Monopoly project. It provides you a very rough idea of what is the project "Monopoly" about.

strains substrate enzyme functional recent forms outcomes synthesis monoterpene construct stereoselectivity chemistry bvmo appropriate native involve terpenoids toolkit mechanisms biocatalytic computational conversion generate proteins yield monooxygenases newly metabolic baeyer enzymes protein biology reactivity catalysis function stability realized readily coenzyme multidisciplinary sustainable monomer specificities training coli successes polyurethanes bayervilliger deep synthetic me producing lactone relationship recognition engineering tools dependent biomaterials variant data area ready biophysical monomers biopolymer suitable flavin structure components structural villiger extend experimental enabled biocatalysts cheap substrates profiles clear proteomics

Project "Monopoly" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	224˙933 €
EC max contribution	224˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-CAR
Starting year	2019
Duration (year-month-day)	from 2019-07-15 to 2021-10-09

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	coordinator	224˙933.00

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Project objective

Recent advances in the development of both experimental and computational protein engineering tools have enabled a number of further successes in the development of biocatalysts ready for large-scale applications.The production of monomers from cheap, readily available components (e.g. terpenoids) for sustainable biopolymer synthesis is a growing area of interest. Biomaterials composed of lactone monomers have been used to produce polyurethanes.The present research proposal is focused on the deep understanding of catalysis by newly identified BVMO enzymes, realized through detailed structural and functional analysis of enzyme mechanisms and substrate/coenzyme recognition. This project will involve multidisciplinary training, with clear objectives in the technical areas of synthetic biology, proteomics, structural biology and biophysical chemistry. This project will allow me to work on structure/function relationship of proteins and to extend my knowledge in metabolic pathway engineering especially in understanding of monooxygenases.The objective will be to identify new Baeyer Villiger monooxygenases biocatalysts that have the appropriate biocatalytic and stability characteristics to enable lactone monomer synthesis. The methods would generate novel structural and biocatalytic data to provide a comprehensive toolkit of flavin-dependent BayerVilliger monooxygenases that are suitable for exploitation in lactone monomer synthesis. These new biocatalysts will be used to construct new strains of E. coli that are capable of producing the target lactone monomers in high yield. The immediate outcomes will be new structural information (native and variant forms of the enzymes); new biocatalytic parameters (reactivity profiles with target substrates; stereoselectivity; conversion; stability; coenzyme specificities) and new lactone producing strains generated from existing monoterpene producing E. coli strains.

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The information about "MONOPOLY" are provided by the European Opendata Portal: CORDIS opendata.