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Opendata, web and dolomites

PAVE SIGNED

A nanovaccine Approach for the treatment of Pancreatic Cancer

Total Cost €

EC-Contrib. €

Partnership

Views

PAVE project word cloud

Explore the words cloud of the PAVE project. It provides you a very rough idea of what is the project "PAVE" about.

met promise relieve highest disease immunomodulating radiotherapy fourth multidisciplinary immune content progression extremely intersectoral abundance therapy 90 immuno cancers men blocking body conventional tme rate fatal efforts duct pancreatic symptoms resistance stages applicable multiple chemo surgery excess shown limited barrier minimal responsible hijacked bowel secondly proliferation residual mortality stromal despite firstly overcoming physical aggressive worldwide nature tumour annum deaths therapies treat hallmark ductal resectable metastatic components immunotherapy 250 modulation biochemical patients multicomponent microenvironment treatment resection ing adenocarcinoma women cancer form group pdac vaccine nanovaccine bile extensive characterised

Project "PAVE" data sheet

The following table provides information about the project.

Coordinator	PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	4˙023˙616 €
EC max contribution	4˙023˙616 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2023-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	265˙619.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	531˙239.00
3	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	505˙576.00
4	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	303˙172.00
5	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	297˙522.00
6	POLYPURE AS POLYPURE AS Organization address address: GAUSTADALLEEN 21 city: OSLO postcode: 349 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	292˙342.00
7	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	274˙802.00
8	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	265˙619.00
9	GOOD BIOMARKER SCIENCES BV GOOD BIOMARKER SCIENCES BV Organization address address: TEIJLINGERLAAN 59 city: SASSENHEIM postcode: 2171 CD website: www.gbsleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SASSENHEIM)	participant	265˙619.00
10	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	265˙619.00
11	KLINIKUM DER UNIVERSITAET REGENSBURG KLINIKUM DER UNIVERSITAET REGENSBURG Organization address address: FRANS JOSEF STRAUSS ALLEE 11 city: REGENSBURG postcode: 93053 website: www-cgi.uni-regensburg.de/Klinik/Klinikum/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REGENSBURG)	participant	252˙788.00
12	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	252˙788.00
13	UNIVERSITAT DE BARCELONA UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 website: http://www.ub.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	250˙904.00

Map

Project objective

A Nanovaccine Approach For The Treatment of Pancreatic Cancer By Multicomponent Immuno-Modulation: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in men and women and still fatal in over 90% of patients. It is characterised by its extremely aggressive nature where it is also responsible for the highest mortality rate compared to other major cancers, resulting in excess of 250,000 deaths worldwide per annum. Current state-of-art therapies for advanced PDAC including chemo- and/or radiotherapy, despite extensive efforts, have met with only limited success. Surgery is only applicable for those with early stages of the disease, or to relieve symptoms, if the cancer is blocking the bile duct or the bowel. There are two major reasons for the resistance of PDAC to conventional therapy. Firstly, PDAC has a very defining hallmark, where an abundance of stromal content is present in the tumour microenvironment (TME) to form a physical and biochemical barrier. Secondly, during progression of the disease, the body's immune system is hijacked to support the proliferation of the cancer. New approaches, such as immunotherapy, are therefore needed where it has already shown promise in overcoming many aspects of this resistance. Immunotherapy has the potential to treat minimal residual disease after pancreatic resection (surgery) as well as for metastatic and non-resectable PDAC. Our objective for this project is to bring together a multidisciplinary and intersectoral group to develop novel vaccine approaches, including use of multiple immunomodulating components.

Publications

List of publications.
year	authors and title	journal	last update
2020	Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17Î±-Methyltestosterone Delivery published pages: 1181, ISSN: 1420-3049, DOI: 10.3390/molecules25051181	Molecules 25/5	2020-04-15

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The information about "PAVE" are provided by the European Opendata Portal: CORDIS opendata.