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Magicbullet Reloaded SIGNED

Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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Magicbullet Reloaded project word cloud

Explore the words cloud of the Magicbullet Reloaded project. It provides you a very rough idea of what is the project "Magicbullet Reloaded" about.

substantially agent pdcs pharmacokinetic environment vision discovery cell drugs reloaded had builds array magic special outstanding basis overcome delivered esrs expand scientific nobel made expert brings industry acquired stimulate resistance etn despite efforts successful magicbullet conjugates smdcs organic medicinal pipeline premature consequence drug cancer efficient biochemistry continuing synthesize compound recruited cells tumor disease death perfectly selectivity direction ideal 2015 complementarity refers ehrlich bullet molecule faceted toxin treatments immune versa 2018 grant physiology interdisciplinary kills 642004 expanded antigens pharmacology peptide worldwide academia therapy bold causing organism competences immuno vice tissue investigation broad exposed therapeutic chemistry paul selectively biology laureate title small antitumor implication idea 1908

Project "Magicbullet Reloaded" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	3˙915˙902 €
EC max contribution	3˙915˙902 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2019
Duration (year-month-day)	from 2019-11-01 to 2023-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	coordinator	252˙788.00
2	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	303˙172.00
3	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	281˙276.00
4	PHILOCHEM AG PHILOCHEM AG Organization address address: LIBERNSTRASSE 3 city: OTELFINGEN postcode: 8112 website: www.philochem.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (OTELFINGEN)	participant	281˙276.00
5	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	280˙805.00
6	EXIRIS SRL EXIRIS SRL Organization address address: VIA SAVONA INT 2 B 6 city: ROMA postcode: 182 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	261˙499.00
7	TAKIS SRL TAKIS SRL Organization address address: VIA DI CASTEL ROMANO 100 city: ROMA postcode: 128 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	261˙499.00
8	UNIVERSITA DEGLI STUDI DELL'INSUBRIA UNIVERSITA DEGLI STUDI DELL'INSUBRIA Organization address address: VIA RAVASI 2 city: VARESE postcode: 21100 website: www.uninsubria.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VARESE)	participant	261˙499.00
9	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	261˙499.00
10	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	252˙788.00
11	HEIDELBERG PHARMA RESEARCH GMBH HEIDELBERG PHARMA RESEARCH GMBH Organization address address: SCHRIESHEIMER STRASSE 101 city: LADENBURG postcode: 68526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LADENBURG)	participant	252˙788.00
12	TECHNISCHE UNIVERSITAT DARMSTADT TECHNISCHE UNIVERSITAT DARMSTADT Organization address address: KAROLINENPLATZ 5 city: DARMSTADT postcode: 64289 website: www.tu-darmstadt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	participant	252˙788.00
13	UNIVERSITAET ZU KOELN UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50931 website: www.uni-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	252˙788.00
14	EOTVOS LORAND TUDOMANYEGYETEM EOTVOS LORAND TUDOMANYEGYETEM Organization address address: EGYETEM TER 1-3 city: BUDAPEST postcode: 1053 website: www.elte.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	229˙715.00
15	Orszagos Onkologiai Intezet Orszagos Onkologiai Intezet Organization address address: RATH GYORGY UTCA 7-9. city: Budapest postcode: 1122 website: www.oncol.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (Budapest)	participant	229˙715.00

Map

Project objective

'Despite the continuing development of new and more efficient treatments, cancer remains the second cause of premature death worldwide. Multi-faceted interdisciplinary research efforts in industry and academia on different aspects of cancer have provided a knowledge basis for the development of novel therapeutic approaches. Paul Ehrlich, Nobel laureate in Physiology of 1908, had the early vision that a compound could be made to selectively target a disease-causing organism or tumor. A toxin for the particular tissue could be delivered by an agent of selectivity. Such an ideal therapeutic agent would be a 'magic bullet' that only kills the target cells. This ETN initiative with the title Magicbullet::reloaded refers to Ehrlich’s bold idea and builds on the previous experience of the highly successful ETN MAGICBULLET (2015-2018, grant agreement No. 642004). As a consequence of the outstanding results, the ETN Magicbullet::reloaded will expand the field of investigation from peptide-drug conjugates (PDCs) to small molecule-drug conjugates (SMDCs) with a special focus on drugs capable to stimulate tumor immune responses and overcome resistance to immuno-therapy. The consortium has been substantially expanded to perfectly address the needs of the new research direction. The planned ETN will design and synthesize an array of SMDCs (including PDCs), also targeting less investigated tumor antigens, investigate their pharmacokinetic behaviour, their implication on the immune system, as well as their tumor selectivity and antitumor activity. The consortium brings together interdisciplinary expert knowledge in Organic Chemistry, Peptide Chemistry, Medicinal Chemistry, Drug Discovery, Biochemistry, Pharmacology and Cell Biology. This high complementarity is required for the different scientific tasks in the development pipeline. Vice versa, the recruited ESRs will be exposed to a challenging research environment leading to a broad range of scientific competences to be acquired.'

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The information about "MAGICBULLET RELOADED" are provided by the European Opendata Portal: CORDIS opendata.

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