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HUGODECA SIGNED

Human Gonad Developmental Cell Atlas

Total Cost €

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EC-Contrib. €

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Partnership

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HUGODECA project word cloud

Explore the words cloud of the HUGODECA project. It provides you a very rough idea of what is the project "HUGODECA" about.

unprecedented culture executives public transcriptomics clinicians mechanisms developmental integrate integration active vixo testes gonads ongoing disorders medical altering scientists pediatric synergistic image male countries mimicking reference differences lineages accompany interactive mass online academic cleared imaging brings ground understand multiscale platforms grounded accuracy hugodeca underlying males 3d sex multiple data diverge maps ex cellular efforts female dimensional models events care contributors healthy portal ovaries breaking signaling tools cytometry expertise assays human composition tested technologies molecular spatial divergence associations gonadal patient treatment omics immunofluorescence cyclic specialized computational dsd cell atlas multidimensional complementarity industrial single vivo model requiring differentiation emerge first profiling analytical traits organization gonad psychosocial optically experts females embryonic describe hca 2d

Project "HUGODECA" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	4˙822˙198 €
EC max contribution	4˙822˙197 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙820˙748.00
2	GENOME RESEARCH LIMITED GENOME RESEARCH LIMITED Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE website: http://www.sanger.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	725˙810.00
3	KEEN EYE TECHNOLOGIES KEEN EYE TECHNOLOGIES Organization address address: 74 RUE DU FAUBOURG SAINT ANTOINE INCUBATEUR INSTIT DE LA VISION city: PARIS postcode: 75012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	543˙750.00
4	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	402˙800.00
5	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	354˙625.00
6	INSERM - TRANSFERT SA INSERM - TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	320˙450.00
7	MILTENYI BIOTEC GMBH MILTENYI BIOTEC GMBH Organization address address: FRIEDRICH EBERT STRASSE 68 city: BERGISH GLADBACH postcode: 51429 website: www.miltenyibiotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERGISH GLADBACH)	participant	242˙812.00
8	CARTANA AB CARTANA AB Organization address address: NOBELS VAG 3 city: SOLNA postcode: 171 65 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	participant	206˙250.00
9	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	204˙952.00

Map

Project objective

The single ground-breaking goal of the HUGODECA project is to describe the cellular composition and organization of the developing human gonads and to understand how it changes during sex determination into testes in males and ovaries in females. What are the underlying mechanisms and first molecular and cellular events that accompany the differentiation and divergence of embryonic gonads? How and when do male and female cell lineages diverge and specific traits emerge? HUGODECA focuses on healthy gonad development, but our reference model will be tested using specific ex vixo assays mimicking Differences/Disorders of Sex Development (DSD). To reach this ambitious goal, the HUGODECA consortium brings together leading European academic and industrial experts (from 5 different EU countries). It includes active contributors and executives of the Human Cell Atlas (HCA) which will ensure complementarity with other ongoing HCA efforts. The overall HUGODECA concept is grounded on the integration of multiple synergistic expertise and technologies: Single cell profiling, Spatial transcriptomics, 2D Mass cytometry and cyclic immunofluorescence and 3D imaging of optically cleared gonads. HUGODECA will implement novel tools, analytical and computational methods to process and integrate multidimensional OMICS and image data across different platforms. It will evaluate the accuracy of ex vivo culture models of human gonadal development and assess consequences of altering key signaling pathways. HUGODECA will build the first multiscale developmental cell atlas and unprecedented reference maps of male and female human gonads. It will implement an interactive and multi-dimensional online portal for clinicians, scientists and public including DSD patient associations. HUGODECA shall improve our understanding of DSD, which is a major pediatric concern, requiring complex and highly specialized medical treatment and psychosocial care.

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The information about "HUGODECA" are provided by the European Opendata Portal: CORDIS opendata.

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