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HDM-FUN SIGNED

Host directed medicine in invasive fungal infection

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HDM-FUN project word cloud

Explore the words cloud of the HDM-FUN project. It provides you a very rough idea of what is the project "HDM-FUN" about.

signalling    intensive    ifi    aspergillosis    morbidity    managed    medicine    tests    hdm    health    point    scientists    candidemia    metabolomics    brings    modulators    genetics    unacceptably    mortality    medical    fun    regulation    treatment    observational    risk    influenza    phagosome    inflammasome    interactions    fungal    centralize    unravel    outcome    proposes    transcription    immune    prospective    metabolome    transdisciplinary    susceptibility    teaching    protocols    experts    tools    strategies    enrolled    infrastructure    disease    immunotherapy    infection    care    biogenesis    personalized    patients    professionals    pathogen    therapeutic    infections    stratify    standardize    explore    preventive    first    believe    overcome    microbiome    biobank    efforts    trials    setting    hpfs    clinical    invasive    lethal    trial    diagnostic    prophylaxis    interventions    immunology    designing    options    samples    despite    directed    experimental    correlate    centrally    host    translate   

Project "HDM-FUN" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 10˙158˙439 €
 EC max contribution 9˙998˙170 € (98%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙811˙150.00
2    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 1˙220˙750.00
3    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 703˙000.00
4    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 692˙185.00
5    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 684˙000.00
6    DUKE UNIVERSITY US (DURHAM NC) participant 592˙750.00
7    Hycult biotechnology bv NL (Uden) participant 400˙000.00
8    INNOVATION ACTA S.R.L. IT (ROMA) participant 350˙500.00
9    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 345˙750.00
10    UNIVERSITA DEGLI STUDI DI PERUGIA IT (PERUGIA) participant 322˙450.00
11    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) participant 320˙010.00
12    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) participant 319˙950.00
13    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 319˙750.00
14    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) participant 319˙700.00
15    UNIVERSIDADE DO MINHO PT (BRAGA) participant 319˙625.00
16    UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA RO (Cluj-Napoca) participant 276˙600.00

Map

 Project objective

Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind. The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care. Specific objectives: 1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options. 2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis. 3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis. 4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals. HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.

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The information about "HDM-FUN" are provided by the European Opendata Portal: CORDIS opendata.

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