CELLULO-EPI SIGNED
Celluloepidemiology: a novel paradigm for modeling T-cell responses on a population level.
Total Cost €
0EC-Contrib. €
0Partnership
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Project "CELLULO-EPI" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT ANTWERPEN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 1˙499˙734 € |
| EC max contribution | 1˙499˙734 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-03-01 to 2025-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT ANTWERPEN | BE (ANTWERPEN) | coordinator | 1˙499˙734.00 |
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Project objective
As a paediatrician who specialized in immunology and as a physicist who specialized in mathematical modeling of infectious diseases, I want to introduce with this project a paradigm shift in infectious disease epidemiology through the concept of celluloepidemiology.
Celluloepidemiology is a term I invented to describe my proposed interdisciplinary approach combining unique cellular immune responses against pathogens on a population level with mathematical modeling, thereby generating unique and otherwise not obtainable multidimensional T-cell profiles.
CELLULO-EPI will develop and use such a highly innovative model to simulate how T-cells against pathogens evolve in a synthetic population as a function of age, gender, time since infection and other relevant variables. This model will be parameterized and fitted by cross sectional T-cell data against a wide set of pathogens from 500 individuals (sampled again after 1 year), unique data from individuals with known first infections with dengue and measles and longitudinal data from individuals re-exposed to chickenpox and parvovirus B19.
The insights of CELLULO-EPI will be pivotal for public health. One important example: Varicella-zoster virus (VZV) causes chickenpox but also shingles after VZV reactivation. Vaccination can prevent chickenpox, but the predicted increase in shingles incidence has blocked chickenpox vaccination in many EU-countries. Indeed, re-exposure to chickenpox is hypothesized to protect against shingles through boosting of T-cells. Unfortunately, none of the available epidemiological or immunological tools allow for adequate validation of the boosting hypothesis. However, CELLULO-EPI will be able to solve this persisting VZV vaccination dilemma. Furthermore, CELLULO-EPI will also redefine infectious disease epidemiology, for example by allowing us to back-calculate the time since last exposure.
I am convinced CELLULO-EPI can revolutionize infectious disease epidemiology and public health.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CELLULO-EPI" project.
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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
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The information about "CELLULO-EPI" are provided by the European Opendata Portal: CORDIS opendata.
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