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GONOGO SIGNED

Multi-layered integration of motivated actions and their outcomes in basal ganglia circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GONOGO project word cloud

Explore the words cloud of the GONOGO project. It provides you a very rough idea of what is the project "GONOGO" about.

translational    independent    crucially    basis    constitutes    rats    interaction    monitoring    valence    ensemble    initiation    interacts    neural    input    valences    traffic    optogenetic    made    respectively    impaired    rewarding    actions    output    position    track    dysfunctional    potentially    light    red    manipulation    behavioral    neuronal    modulating    innovative    transgenic    hypothesize    mosquito    indirect    cross    fellowship    repellant    wait    treatment    implantable    chances    basal    suffering    depression    action    dopamine    receive    stimuli    suppression    disciplinary    aversive    anatomical    impulsivity    imaging    direct    street    tailor    outcome    brain    ganglia    implicated    mechanisms    serotonin    calcium    opposing    tenure    govern    strengthen    interface    miniaturized    supports    incomplete    psychiatric    inform    functional    simultaneous    understand    neurons    inter    anticipated    integration    researcher    green    patients    cream    fluorescence    bite    paradigm    microscopes    insect    disorders    performing    ice   

Project "GONOGO" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 187˙572.00

Map

 Project objective

We cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.

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The information about "GONOGO" are provided by the European Opendata Portal: CORDIS opendata.

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