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GONOGO SIGNED

Multi-layered integration of motivated actions and their outcomes in basal ganglia circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GONOGO project word cloud

Explore the words cloud of the GONOGO project. It provides you a very rough idea of what is the project "GONOGO" about.

patients    innovative    ensemble    receive    researcher    position    indirect    strengthen    disciplinary    neural    imaging    red    cream    output    neuronal    traffic    brain    basis    optogenetic    implicated    integration    constitutes    inform    interface    rats    outcome    aversive    mosquito    green    direct    anatomical    valence    inter    tenure    street    basal    calcium    supports    simultaneous    insect    paradigm    performing    disorders    opposing    hypothesize    microscopes    action    dysfunctional    translational    suffering    suppression    fluorescence    behavioral    treatment    rewarding    interacts    monitoring    modulating    anticipated    tailor    independent    mechanisms    functional    track    stimuli    psychiatric    ganglia    ice    neurons    actions    incomplete    understand    made    depression    impaired    chances    miniaturized    wait    cross    repellant    dopamine    manipulation    serotonin    interaction    potentially    valences    initiation    crucially    transgenic    fellowship    implantable    bite    govern    input    impulsivity    respectively    light   

Project "GONOGO" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 187˙572.00

Map

 Project objective

We cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.

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The information about "GONOGO" are provided by the European Opendata Portal: CORDIS opendata.

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