STIMULATE SIGNED
STING signalling modulation via the Electron Transport Chain
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0STIMULATE project word cloud
Explore the words cloud of the STIMULATE project. It provides you a very rough idea of what is the project "STIMULATE" about.
Project "STIMULATE" data sheet
The following table provides information about the project.
| Coordinator |
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 160˙932 € |
| EC max contribution | 160˙932 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-07-01 to 2023-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) | ES (MADRID) | coordinator | 160˙932.00 |
Map
Project objective
The innate immune response to cytosolic dsDNA via the cGAS-STING pathway has been shown to be essential in the response to various viral, bacterial and parasitic infections, in autoimmunity and in cancer. However, the relationship between STING signalling and metabolism is currently unknown. In recent years, our understanding of immunometabolism has also increased – it is becoming clear that metabolic adaptations are fundamental for immune responses. Due to its role in this wide range of clinical pathologies, the mechanism of STING signalling has received a great deal of scientific interest and several STING-targeting compounds are now reaching clinical trial stages of development. It is therefore important to understand the effect of STING activation on mammalian cells, as well as how to manipulate this response to the greatest effect. The research proposed here focuses on the relationship between cellular metabolism and innate immune signalling via STING, using an unbiased proteomics approach as well as targeted immunometabolism approaches to find STING modulating metabolic pathways. Having completed my PhD studies in immunology, I am pursuing a postdoctoral project, in the lab of Dr. David Sancho at the CNIC, that utilises my expertise and allows me to expand my technical horizons and enhance my career development. As an expert in innate immune signalling I believe that combining my knowledge with the Sancho lab’s expertise in cellular immunobiology and metabolism will lead to a better understanding of our immune system. As well as the expertise of my host lab, I will also benefit from the collaboration of leaders in proteomics and mitochondrial biology. This Individual Fellowship would greatly benefit my current research objectives and my career as a whole by allowing me to explore my research interests in a supportive environment, where I will receive the training required for the next stage of my research career.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STIMULATE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "STIMULATE" are provided by the European Opendata Portal: CORDIS opendata.