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StartAct SIGNED

Controlling forelimb actions through basal ganglia to brainstem signaling

Total Cost €

EC-Contrib. €

Partnership

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StartAct project word cloud

Explore the words cloud of the StartAct project. It provides you a very rough idea of what is the project "StartAct" about.

career experiments unknown operations reticular inputs parkinson excellent motor reaching machinery brainstem forelimb behavioral cord isolate actors disclose mechanisms initiating circuit parvocellular arber nigra opportunity self neuronal designed output signaling nature impaired distributed reticulata connections blocks stone movement harbors executive leader independent movements unravel lab discovered projections poorly inhibitory fine actions physically supports combination basal stepping behaviors disease neurons centers function mouse group initiates expand me snr therapies anatomy foundations linked gain fellowship perturbations designing expertise sends spinal substantia architecture understand action events receive combine pcrt building monitoring circuits people behavior initiated arises ganglia

Project "StartAct" data sheet

The following table provides information about the project.

Coordinator	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 website: www.fmi.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	203˙149 €
EC max contribution	203˙149 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2021
Duration (year-month-day)	from 2021-09-01 to 2023-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 website: www.fmi.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	coordinator	203˙149.00

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Project objective

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood. The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions. I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions. Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "STARTACT" are provided by the European Opendata Portal: CORDIS opendata.