HERGSCREEN

hERG related risk assessment of botanicals

Coordinatore	UNIVERSITAT WIEN    more  Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 contact info Titolo: Prof. Nome: Steffen Cognome: Hering Email: send email Telefono: 431428000000 Fax: 43142779553
Nazionalità Coordinatore	Austria [AT]
Totale costo	314˙700 €
EC contributo	308˙700 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2016-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAT WIEN  Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 contact info Titolo: Prof. Nome: Steffen Cognome: Hering Email: send email Telefono: 431428000000 Fax: 43142779553	AT (WIEN)	coordinator	90˙300.00
2	NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS  Organization address address: CHRISTOU LADA 6 city: ATHENS postcode: 10561 contact info Titolo: Ms. Nome: Efi Cognome: Kafentzi Email: send email Telefono: 302104000000 Fax: 302104000000	EL (ATHENS)	participant	86˙100.00
3	UNIVERSITAET BASEL  Organization address address: Petersplatz 1 city: BASEL postcode: 4003 contact info Titolo: Prof. Nome: Matthias Cognome: Hamburger Email: send email Telefono: 41612671425 Fax: 41612671474	CH (BASEL)	participant	56˙700.00
4	UNIVERSITAET INNSBRUCK  Organization address address: INNRAIN 52 city: INNSBRUCK postcode: 6020 contact info Titolo: Dr. Nome: Kurt Cognome: Habitzel Email: send email Telefono: +43 512 507 9051 Fax: +43 512 507 2607	AT (INNSBRUCK)	participant	44˙100.00
5	"BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"  Organization address address: Soranou Efesiou 4 city: ATHENS postcode: 11527 contact info Titolo: Dr. Nome: Constantin Cognome: Tamvakopoulos Email: send email Telefono: 302107000000 Fax: 302107000000	EL (ATHENS)	participant	31˙500.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'The main goal of this project is the establishment of a network between European, South American, North American and South African educational and research entities. This attempt will be based on an innovative scientific project aiming towards the identification of hERG (human Ether-à-go-go Related Gene) channel blockers in commonly consumed botanicals and supplements. Blocking these ion channels may result in ventricular tachyarrhythmia and an increased incidence of sudden death. Thus, the hERG channel is considered as an important antitarget. Several drugs have been removed from the market for this reason, and compounds have been blocked from proceeding further into phases of clinical development. As botanicals (comprising dietary supplements, spices, herbal medicinal products) continue to increase in popularity there is an urgent need for studies aimed to critically assess the potential cardiotoxic risks of these products.

State-of-the-art methodologies and techniques will be incorporated for target-oriented identification and isolation of hERG channel blocking constituents. PK and PD studies will be performed and LC-MS based methods will be developed and applied towards the measurement of bioactive components in biofluids samples. Comparison of biofluids derived from administration of single chemical entities and corresponding botanicals will be achieved using MS- and NMR-based metabolomics. The obtained results will help to elaborate and evaluate hERG related safety aspects aiming towards the risk assessment of frequently consumed botanicals.

Within this frame numerous short term and extended secondments of scientific staff will be accomplished, while the organization of several workshops will assure the proper dissemination of the produced knowledge throughout all the scientific community but also the public. Core scientific knowledge is expected to be produced and exchanged, and partnerships with future scientific potentials to be created.'