GENBLAST

Investigating the biology of plant infection by the rice blast fungus Magnaporthe oryzae

Coordinatore	THE UNIVERSITY OF EXETER    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙498˙733 €
EC contributo	2˙498˙733 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-ADG_20110310
Funding Scheme	ERC-AG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2017-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EXETER  Organization address address: Northcote House, The Queen's Drive city: EXETER postcode: EX4 4QJ contact info Titolo: Ms. Nome: Gaynor Cognome: Hughes Email: send email Telefono: +44 1392 725835 Fax: +44 1392 263686	UK (EXETER)	hostInstitution	2˙498˙733.00
2	THE UNIVERSITY OF EXETER  Organization address address: Northcote House, The Queen's Drive city: EXETER postcode: EX4 4QJ contact info Titolo: Prof. Nome: Nicholas Cognome: Talbot Email: send email Telefono: +44 1392 723006 Fax: +44 1392 723008	UK (EXETER)	hostInstitution	2˙498˙733.00

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 Obiettivo del progetto (Objective)

'Plant diseases represent one of the most important risks to ensuring global food security and new control strategies for the world’s most serious crop diseases are urgently needed. This project will lead to an unparalleled advance in understanding of the world’s most serious crop disease - rice blast. Each year rice blast disease claims 11-30% of the potential rice harvest, which is enough rice to feed 60 million people. The fungus that causes rice blast disease, Magnaporthe oryzae, is a highly adapted cereal pathogen, which forms specialized infection structures called appressoria that can breach the intact leaf surface and allow the fungus entry to living plant tissue. This project will result in the most comprehensive understanding of the biology of plant infection by a pathogenic fungus. The cross-disciplinary research programme will integrate next generation DNA sequencing, digital transcriptional profiling, and high throughput gene functional analysis, with cell biology and live cell imaging. In this way, the transcriptional networks and gene regulators of fungal virulence will be identified and characterized at a systems level. The project will investigate the nature of the host-pathogen interface using live cell imaging of stable transgenic rice lines expressing fluorescent fusion proteins that define specific sub-cellular domains and will allow the precise mechanism of cellular invasion by the fungus to be determined. The project will also use protein-protein interaction studies to identify the major effectors used by M. oryzae to suppress plant immunity and facilitate proliferation of the fungus within living plant tissue. In parallel, comparative genome analysis will define conserved the full repertoire of effector functions and the transcriptional networks necessary for plant disease. Comprehensive functional analysis of M. oryzae effectors will then be carried out by targeted gene deletion, spatial localization and target identification.'