EPIGAM2

Epigenetics and chromatin dynamics in gametes : using yeast spores and advanced proteomics

Coordinatore	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES    more  Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Ms. Nome: Haiyet Cognome: Chebli Email: send email Telefono: +33 4 38 78 90 15 Fax: +33 4 38 78 50 55
Nazionalità Coordinatore	France [FR]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2016-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES  Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Ms. Nome: Haiyet Cognome: Chebli Email: send email Telefono: +33 4 38 78 90 15 Fax: +33 4 38 78 50 55	FR (PARIS 15)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'The field of epigenetics has been developing exponentially over the last decade. However, the organization of chromatin in gametes is still poorly understood. The role of this organization in fertilization and early embryonic development is largely unknown.

For many years, I have been exploring different aspects of chromatin organization and dynamics during male gamete differentiation. The study of gametogenesis has proven to be technically challenging. My post-doctorate work, realized in the USA, demonstrated that a simple model, yeast sporulation, shares functional similarities with mammalian spermatogenesis. Taking advantage of this observation, I propose to deploy a new research program, EPIGAM2, using yeast sporulation as a powerful model for mammalian spermatogenesis.

EPIGAM2 will be hosted by the group “Exploring the Dynamics of Proteomes”, directed by Jérôme Garin (Grenoble, France). The partnership between the candidate and the host laboratory has long-term interests, reinforcing cooperation between fundamental research and the development of new methodologies in proteomics. Indeed, EPIGAM2 combines multi-dimensional approaches using genetic, biochemical, and proteomic techniques. Project management has been carefully planned, and tasks, risk analyses, and milestones are presented. Support from this Marie Curie Action is vital for the launch of this research program, allowing the complete reintegration of the candidate and adequate development of his research program.

To conclude, EPIGAM2 research program is based on a unique combination of (i) an innovative biological question, with potential implications for fertility care, cancer biology, and regenerative medicine, (ii) an original biological model, yeast spores, validated by several high profile publications, (iii) the impact of the program on the career of the candidate, the scientific community and outreach activities.'