NEUROPROTEIN PROFILE

Large-scale protein expression profiling of genes implicated in cognitive disorders and dissection of their role in neural tissue development and plasticity

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Dr. Nome: Birgit Cognome: Knepper-Nicolai Email: send email Telefono: +49 351 2102772 Fax: +49 351 2101089
Nazionalità Coordinatore	Germany [DE]
Totale costo	167˙390 €
EC contributo	167˙390 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-04-01   -   2015-07-13

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Dr. Nome: Birgit Cognome: Knepper-Nicolai Email: send email Telefono: +49 351 2102772 Fax: +49 351 2101089	DE (MUENCHEN)	coordinator	167˙390.40

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 Obiettivo del progetto (Objective)

Cognitive disorders are, due to their high frequency and lifelong costs, a leading medical and socio-economical problem world-wide. Particularly for the large number of disorders characterized by intellectual disability, no therapy is available. The search for effective treatment is unlikely to be successful until the pathology of these disorders is better understood. Currently mutations in around 300 human genes are known to cause cognitive disorders. These genes provide an exciting molecular window into fundamental neuroscience and translational research. In 2010, a large international project, FP7 GENCODYS, has been started to characterize their function on the large scale. An early outcome of this project is a systematic library of Drosophila strains that express the fly homologs of human cognitive disorder disease genes as fluorescently tagged (and thus easily traceable) proteins, under their endogenous genomic regulatory control. Combining this novel native reporter toolbox with modern microscopy techniques I propose to create and assemble high-resolution 3D maps of gene expression profiles of these genes in the nervous tissue during embryonic development and in the adult brains of fruitflies, the two conditions most relevant to their associated human disease pathologies. Adult gene expression patterns will be generated under both the steady-state and the stimulated brain activity conditions in order to uncover key factors of neuronal plasticity. We expect these unique charts of plastic neuronal activity to significantly contribute to our understanding of higher brain function in health and disease. They will also facilitate the identification of common molecular pathways that can be targeted for effective treatment of cognitive disorders.