INTEGRAGEING

Modelling human ageing: developing and interrogating an integrated model of ageing to identify causal relationships between hormonal changes and gene expression changes

Coordinatore	THE UNIVERSITY OF LIVERPOOL    more  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Catherine Cognome: Cowton Email: send email Telefono: +44151 794 4688
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	200˙371 €
EC contributo	200˙371 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-11-15   -   2014-11-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Catherine Cognome: Cowton Email: send email Telefono: +44151 794 4688	UK (LIVERPOOL)	coordinator	200˙371.80

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 Obiettivo del progetto (Objective)

'Ageing has a profound impact on human society and modern medicine, yet it remains a major puzzle of biology. Both hormonal and gene expression changes have been implicated as causal mechanisms of ageing. It is not clear, however, which molecular or physiological changes are more important drivers of the process of ageing or how they influence each other. This project aims to develop and interrogate an integrated model of ageing to identify causal relationships between age-related changes at different biological levels. Specifically, this project aims to: 1) Build a mathematical model of age-related gene expression and hormonal changes with age; 2) Determine the causal relationship between these age-related changes using in silico analyses. 3) Develop a new model of ageing based on the results obtained to highlight the new causal relationships identified.'

Introduzione (Teaser)

EU funding has enabled researchers to investigate the causal mechanisms of ageing to prevent or resolve age-related disorders