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Physical principles of recognition in the immune system

Coordinatore	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	1˙267˙914 €
EC contributo	1˙267˙914 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111012
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-11-01   -   2017-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Aleksandra Maria Cognome: Walczak Email: send email Telefono: +33 01 44 32 25 95	FR (PARIS)	hostInstitution	1˙267˙914.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Julie Cognome: Zittel Email: send email Telefono: 33142349416 Fax: 33142349508	FR (PARIS)	hostInstitution	1˙267˙914.00

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 Obiettivo del progetto (Objective)

'Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent functional properties of biological systems, such as recognition. The diversity of the composition of the immune repertoire emerges as a self-organized process, stimulated by interactions with the environment. The goal of the proposed research is to study the self-organization of the immune repertoire in the face of its pathogenic environment at the molecular and evolutionary level, by using a combination of data analysis and statistical mechanics modeling.

Recent experiments have determined the set of B-cell receptors found in a zebrafish and T-cells in humans – data that allows for theoretical analysis and hypotheses rejection that were never possible before. I will theoretically study the problem of recognition from four unique and complementary directions: - guided by statistical signatures in the data I will propose evolutionary models of how selection and mutation in the sequences lead from the genomic precursors to a functional repertoire of receptors, - I will quantify, under simplifying assumptions, the question of the optimal repertoire for recognition in a varying but partially predictable pathogenic environment using maximum likelihood, - analyzing sequence data I will build probabilistic models to characterize the molecular scenarios that generate the repertoire, - I will use information theory and statistical methods to build data-driven models of the molecular nature of recognition based on yeast display experiments.

Describing interactions between elements of receptor sequences will be an important step towards a physical understanding of recognition in the immune system, a crucial concept in grasping the onset of allergies and auto-immune diseases.'