HAIRBUNDLE

Assembling the puzzle of the operating auditory hair bundle

Coordinatore	INSTITUT PASTEUR    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	2˙495˙000 €
EC contributo	2˙495˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-ADG_20110310
Funding Scheme	ERC-AG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-12-01   -   2017-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Marie-Laure Cognome: Rosso Email: send email Telefono: +33 1 44389526 Fax: +33 1 40613940	FR (PARIS CEDEX 15)	hostInstitution	2˙495˙000.00
2	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Prof. Nome: Christine Cognome: Petit Email: send email Telefono: -145688857 Fax: -140613409	FR (PARIS CEDEX 15)	hostInstitution	2˙495˙000.00

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 Obiettivo del progetto (Objective)

'The hair bundles of the sensory cells play a central role in the processing of sounds by the cochlea. Various performances of auditory perception depend upon what biophysical and physiological environment the operating hair bundle can provide to its mechanoelectrical transduction (MET) channels. The project aims at building a more integrated view of the way the hair bundle works. Reaching this goal, requires to understand the interdependence of its functional building blocks and their dynamic interplay. To this purpose, the objectives of the work are : 1. To assemble components of the basal MET machinery The work aims at a) identifying the molecular players of the basal MET machinery, most of which are still unknown b) deciphering their functional interactions, c) developing a simple and efficient tool to validate candidate components of the MET machinery. 2. To elucidate the coupling between MET and stereocilia F-actin polymerisation The work aims at a) characterising this coupling, both in development and in steady-state condition, b) deciphering the role of tip-link tension and Ca2 influx through the MET channel, c) developing a coarse-grained mathematical model of this coupling, experimentally testable. 3. To understand the interplay between MET, waveform distortions, and masking The work aims at a) deciphering biochemical characteristics of the top connectors, b) explaining why large waveform distortions vanish in the absence of top connectors, c) determining how the operating outer hair cell (OHC) hair bundle contributes to the masking effect in auditory perception. The hair bundle is a highly vulnerable structure, actually the main target structure of noise-induced hearing loss and hereditary deafness forms. As such, advances in the understanding of the mechanisms underlying its functioning will pave the way for the development of therapeutic approaches.'