JELLY

Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function

Coordinatore	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Spain [ES]
Totale costo	1˙497˙166 €
EC contributo	1˙497˙166 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111012
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-12-01   -   2017-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES  Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 city: SAN SEBASTIAN postcode: 20009 contact info Titolo: Dr. Nome: Ralf Peter Cognome: Richter Email: send email Telefono: +34 943 00 53 29 Fax: +34 943 00 53 15	ES (SAN SEBASTIAN)	hostInstitution	1˙497˙166.80
2	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES  Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 city: SAN SEBASTIAN postcode: 20009 contact info Titolo: Mr. Nome: Alfonso Cognome: Egaña Email: send email Telefono: +34 943 005 300 Fax: +34 943 005 301	ES (SAN SEBASTIAN)	hostInstitution	1˙497˙166.80

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 Obiettivo del progetto (Objective)

'Certain proteins and glycans self-organize in vivo into soft and strongly hydrated, dynamic and gel-like supramolecular assemblies. Among such biomolecular hydrogels are the jelly-like matrix that is formed around the egg during ovulation, mucosal membranes, slimy coats produced by bacteria in biofilms, and the nuclear pore permeability barrier. Even though biomolecular hydrogels play crucial roles in many fundamental biological processes, there is still a very limited understanding about how they function. Our goal is to assess and to understand the relation between the organizational and dynamic features of such supramolecular assemblies, their physicochemical properties, and the resulting biological functions. We will investigate these relationships directly on the supramolecular level, a level that - for this type of assemblies - is hardly accessible with conventional approaches. To this end, we use purpose-designed in vitro model systems that are well-defined in the sense that their composition and supramolecular structure can be controlled and interrogated. These tailor-made models, together with a toolbox of surface-sensitive in situ analysis techniques, permit tightly controlled and quantitative experiments. Combined with polymer physics theory, the experimental data allow us to directly test existing hypotheses and to formulate new hypotheses that can be further tested in complementary molecular and cell-based assays. This project focuses on two types of biomolecular hydrogels: (i) the nuclear pore permeability barrier, a nanoscopic protein meshwork that regulates all macromolecular transport into and out of the nucleus of eukaryotic cells, and (ii) extracellular hydrogel-like matrices that are scaffolded by the polysaccharide hyaluronan and that are of prime importance in a wide range of physiological and pathological processes including inflammation, fertilization and osteoarthritis.'