REFINE

"Phenotypic plasticity, animal welfare, and the validity of animal experiments."

Coordinatore	UNIVERSITAET BERN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	1˙333˙140 €
EC contributo	1˙333˙140 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-ADG_20120314
Funding Scheme	ERC-AG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2018-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET BERN  Organization address address: Hochschulstrasse 4 city: BERN postcode: 3012 contact info Titolo: Ms. Nome: Maddalena Cognome: Tognola Email: send email Telefono: +41 31 6314809 Fax: +41 31 6315106	CH (BERN)	hostInstitution	1˙333˙140.00
2	UNIVERSITAET BERN  Organization address address: Hochschulstrasse 4 city: BERN postcode: 3012 contact info Titolo: Prof. Nome: Hanno Cognome: Würbel Email: send email Telefono: +41 31 6312530 Fax: +41 31 6312615	CH (BERN)	hostInstitution	1˙333˙140.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Using animals for research is a privilege granted by society to scientists on the explicit understanding that such use will provide significant new knowledge, and no unnecessary harm will be imposed on the animals. However, a high prevalence of abnormal behaviour and other signs of distress in animals housed under standard laboratory conditions, and poor reproducibility of experimental results, suggest that current practice needs to improve to guarantee sound science. Recently we have shown in mice that standard housing conditions may interfere with behavioural control mechanisms expressed as overt behavioural disorders. These findings question both the animals’ welfare and the validity of research conducted with them. Furthermore, we have shown that current practice of standardisation may compromise the external validity of experimental results, resulting in poor reproducibility and spurious results. The overall hypothesis underlying this project is that both impaired welfare and poor reproducibility are caused by a failure to account for fundamental principles of phenotypic plasticity, whereby animal welfare is impaired when the animals’ adaptive plasticity is overtaxed, and reproducibility is compromised when phenotypic variation is standardised away. Based on this framework, the project, therefore, aims to systematically assess environmental effects on the welfare of laboratory animals and on the validity and reproducibility of animal experiments, using the mouse as a model species. The new results should greatly advance our understanding of environmental effects on the quality of life of laboratory animals and on the quality of science conducted with them. They should help to reconcile laboratory animal science with the biological principles of phenotypic plasticity, thereby providing significant new knowledge for effective Refinement of animal research. This should benefit the science as well as the animals in the best meaning of the 3R concept.'