INVIVO_RA_NONCANON

Non-canonical signalling pathways relayed by retinoic acid affecting germ cell differentiation

Coordinatore	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE    more  Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 contact info Titolo: Dr. Nome: Steve Cognome: Brooks Email: send email Telefono: 33388653394
Nazionalità Coordinatore	France [FR]
Totale costo	261˙384 €
EC contributo	261˙384 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-01   -   2015-06-20

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE  Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 contact info Titolo: Dr. Nome: Steve Cognome: Brooks Email: send email Telefono: 33388653394	FR (ILLKIRCH GRAFFENSTADEN)	coordinator	261˙384.60

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 Obiettivo del progetto (Objective)

'Cell proliferation, differentiation and death are controlled by different transcription factors amongst which the non-steroid nuclear receptors (nsNR). Deciphering the mechanisms of action of nsNR is a challenge in various research fields ranging from cancer and neurodegenerative disorders to metabolic diseases. According to the canonical signalling pathway liganded nsNR, in the form of dimers with a rexinoid receptor (RXR), bind to specific DNA response element of target genes and activate transcription. Retinoic acid (RA) receptors (RARs) belong to the nsNR family. RA is the active metabolite of vitamin A, which is indispensable for normal embryonic development and, postnatally, for survival, growth, reproduction and epithelial differentiation. Its properties to induce cell differentiation are used to treat diseases, from benign defects to cancers. According to in vitro data, RARs can act via several non canonical signalling pathways independently of RXR. The InVivo_RA_NonCanon project proposes to characterize such pathways in vivo, using the seminiferous epithelium of the testis as a model system. Working hypotheses have been constructed which integrate yet unpublished data aimed at uncovering genes differentially expressed in RA-deficient contexts and existing datasets identifying RAR binding sites genome wide. The experimental strategy will combine in vitro experiments to identify the mechanisms of action of RARs and in vivo genetic analyses, in the mouse, to test their functionality in a physiological context. Also, InVivo_RA_NonCanon aims at offering to a young scientist with an excellent scientific record, multi-disciplinary training and research experience in the field of cell biology with the goal of broadening the applicant’s skills in science on complementary subjects. The overall mission is to train the young researcher to become an independent scientist as well as to prepare him for a leading position in academia.'