TBKO

Synthesis and Biological Evaluation of a Potent Antituberculosis Natural Product and Analogues

Coordinatore	UNIVERSITE DE GENEVE    more  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Nicolas Cognome: Winssinger Email: send email Telefono: +41 22 379 6526 Fax: +41 22 3793215
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	178˙233 €
EC contributo	178˙233 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IOF
Funding Scheme	MC-IOF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2015-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Nicolas Cognome: Winssinger Email: send email Telefono: +41 22 379 6526 Fax: +41 22 3793215	CH (GENEVE)	coordinator	178˙233.60

Mappa

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 Obiettivo del progetto (Objective)

'This project is directed toward the total synthesis and full structural elucidation of an epidithiodiketopiperazine natural product endowed with highly potent antituberculosis properties and whose full structure and biological evaluation remain incomplete due to its natural scarcity. The proposed research program also includes design, synthesis and biological evaluation of novel analogues of the target molecule as part of an optimization effort, and attempts to identify its biological target. The first year of research and training will be conducted under the supervision of Prof. K.C. Nicolaou (Rice, USA), where the synthesis and compound characterization part of the project will be pursued. In the return phase, the applicant will go to Geneva to work under the supervision of Prof. N. Winssinger (University of Geneva, Switzerland) where the synthesis of the analogues will be performed. The compounds synthesized will be tested for biological activities and evaluated for growth inhibition in a panel of mycobacteria (screeni available through Prof T. Soldati at Geneva).'

Introduzione (Teaser)

European researchers are working on novel drugs based on natural compounds to fight tuberculosis (TB).