PLASTINHIB

Molecular Plasticity of Inhibitory Synapses

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	2˙429˙640 €
EC contributo	2˙429˙640 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-ADG_20120314
Funding Scheme	ERC-AG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2018-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Dr. Nome: Antoine Cognome: Triller Email: send email Telefono: +33 1 44 32 35 47 Fax: +33 1 44 32 36 54	FR (PARIS)	hostInstitution	2˙429˙640.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Laurie Cognome: Louis-Joseph Email: send email Telefono: +33 1 45 17 29 32 Fax: +33 1 45 17 29 11	FR (PARIS)	hostInstitution	2˙429˙640.00

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 Obiettivo del progetto (Objective)

'Neurons maintain a precise organization of their membrane into sub-domains with specific molecular compositions, together with the capacity to change it in response to plasticity events. However, as seen with the tracking of single molecules, receptors in the plasma membrane continuously exchange between synaptic and extrasynaptic locations. Interactions between neurotransmitter receptors and postsynaptic scaffold proteins control the distribution of receptors at synaptic and extrasynaptic sites. This mechanism is modulated at many levels, and contributes to the regulation of the synaptic strength of excitatory and inhibitory synapses in physiological and pathological conditions. This project will address the gap in knowledge between the molecular instability of randomly diffusing receptors and the stable functional architecture of synapses. It will provide new insights into fundamental issues related to the cellular basis of neuronal information processing. Focusing on inhibitory Glycine and GABAA receptors (GlyR, GABAAR) I will have 3 main objectives: Objective 1: to determine key aspects of the relationship between the synapse microstructure, molecular dynamics, and molecular interactions. Objective 2: characterize the mechanisms by which receptor diffusion contributes to the adaptation of inhibitory synapses to excitatory activity. Objective 3: understand how non-neuronal glial cells modulate inhibitory receptor diffusion-trapping and ultimately impact on neuronal excitability. For this research, single molecule methods and super-resolution microscopy give access to molecular dynamics (tracking), the morphology at high resolution, and quantitative data such as dwell times and absolute numbers of molecules, thus identifying new cellular mechanisms accounting for the regulation of inhibitory synaptic strength.'