OMUBAS

Overdominance: from spontaneous mutations to balancing selection in natural populations

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Jocelyn
Cognome: Mere
Email: send email
Telefono: +33 4 67 61 35 35
Fax: +33 4 67 04 32 36

 Nazionalità Coordinatore France [FR]
 Totale costo 194˙046 €
 EC contributo 194˙046 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-12-11   -   2015-12-10

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Jocelyn
Cognome: Mere
Email: send email
Telefono: +33 4 67 61 35 35
Fax: +33 4 67 04 32 36

FR (PARIS) coordinator 194˙046.60

Mappa


 Word cloud

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overdominance    spontaneous    screen    fitness    genetics    alleles    overdominant    experimental    yeast    population    mutations    natural    daphnia    evolution   

 Obiettivo del progetto (Objective)

'Overdominance occurs when individuals carrying two different alleles at a specific locus have higher Darwinian fitness than both homozygotes, who carry only one allele. It is involved in a range of observations in genetics and evolution (e.g. genetic diversity, inbreeding depression, heterosis) and has been controversial for over a century. Empirical studies on the frequency of spontaneous mutations causing overdominance are scarce and there has been no systematic effort to screen for overdominant alleles in any natural population. We propose to (1) test a recent theory predicting that the rate of spontaneous mutations with overdominant effect on fitness increases with maladaptation, and (2) screen for overdominance alleles in a natural population. We propose to use the most appropriate model system for answering each of these questions: Saccharomyces yeast for spontaneous mutations, and Daphnia for segregating alleles. Cutting-edge methods in experimental evolution and quantitative genetics will be used. This project will contribute to the scientific competitiveness of Europe by strengthening a new area of research in France (the scientist in charge will maintain permanent projects using experimental evolution with yeast), providing large libraries of yeast and Daphnia genotypes, and producing high-impact publications.'

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