COMMITMENT
Combined Molecular Microscopy for Therapy and Personalized Medication in Rare Anaemias Treatments
| Coordinatore | UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 7˙730˙292 € |
| EC contributo | 5˙999˙982 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-10-01 - 2018-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
DE (SAARBRUECKEN) | coordinator | 1˙057˙440.00 |
| 2 |
OPTOROBOTIX APS
Organization address
address: N DALHOFFS VEJ 5 contact info |
DK (FREDERIKSBERG) | participant | 922˙075.90 |
| 3 |
EPIGEM LIMITED
Organization address
address: MALMO COURT KIRKLEATHAM BUSINESS contact info |
UK (REDCAR) | participant | 716˙270.10 |
| 4 |
IONSCOPE LIMITED
Organization address
address: MELBOURN SCIENCE PARK ASH HOUSE A2 contact info |
UK (MELBOURN) | participant | 681˙206.60 |
| 5 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 575˙073.30 |
| 6 |
EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Organization address
address: Science Park 1, Stuhlsatzenhausweg 69 contact info |
DE (SAARBRUECKEN) | participant | 566˙800.00 |
| 7 |
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Organization address
address: CALLE ROSSELLO 149 PUERTA BJS contact info |
ES (BARCELONA) | participant | 541˙219.75 |
| 8 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address
address: HEIDELBERGLAAN 100 contact info |
NL (UTRECHT) | participant | 509˙816.53 |
| 9 |
ARIVIS AG
Organization address
address: EINSTEINSTRASSE 10 contact info |
DE (UNTERSCHLEISSHEIM) | participant | 430˙080.00 |
Mappa
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Obiettivo del progetto (Objective)
'The aim of CoMMiTMenT is the development of combined imaging technologies based on optofluidic microscopy and scanning ion conductance microscopy. An integrated, completely simultaneous device named µCOSMOS will be used as a proof-of-principle for therapeutic interventions in rare anaemias. Both techniques rely on molecular detection: optofluidic microscopy relies on molecular biomarkers, and scanning ion conductance microscopy on functional imaging of molecular structures. µCOSMOS allows for the exploration, diagnosis and development of therapeutic interventions for several rare anaemias, including hereditary xerocytosis, overhydrated hereditary stomatocytosis, familial pseudohyperkaliemia, cryohydrocytosis, certain types of spherocytosis, hereditary spherocytosis, sickle cell anaemia, thalassemia and phosphofructokinase deficiency. The non-invasive nature of the combined imaging technologies, which probe the function of molecular effectors, facilitates the testing of medications and their dosage in a personalised manner. For some of the rare anaemias, CoMMiTMenT will provide an initial proof-of-principle, whereas for others, such as sickle cell anaemia, personalised medical interventions should become available and will be tested in clinical practice within the project. CoMMiTMent will ensure an effective therapy with diminished undesirable adverse effects, largely replacing splenectomy.
CoMMiTMenT includes clinical partners and builds a strong relationship with the European Network for Rare and Congenital Anaemias (ENERCA). Furthermore, CoMMiTMenT acts as a bridge between the technology-driven SMEs and ENERCA and, as such, supports the competitiveness of Europe in this area. The applications will advance (personalised) treatment of rare anaemias and, therefore, contribute to the goal of the International Rare Diseases Research Consortium (IRDiRC) to deliver novel diagnostic modalities and 200 new therapies for rare diseases by 2020.'