RNAQUAD

The chemical biology of RNA G-quadruplexes

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙499˙107 €
EC contributo	2˙499˙107 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-ADG
Funding Scheme	ERC-AG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-04-01   -   2019-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	hostInstitution	2˙499˙107.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Prof. Nome: Shankar Cognome: Balasubramanian Email: send email Telefono: +44 1223 336347 Fax: +44 1223 336362	UK (CAMBRIDGE)	hostInstitution	2˙499˙107.00

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 Obiettivo del progetto (Objective)

'For over a decade, our research programme has focused on the chemical biology of nucleic acids. The structure of nucleic acids is key to their biological functions, and the four-stranded guanine rich class of structures called G-quadruplexes constitute a particularly intriguing motif. Recent evidence suggests a role for G-quadruplex (G4) structures in RNA leaving their fundamental importance in biology open for exploration. Our central hypothesis is that the G4 structural motif, rather than its sequence per se, conveys important function(s) in RNA. We propose to directly address this hypothesis by the experimental identification of functional RNA G4 structures within the cellular transcriptome on a genome-wide scale. In particular, we intend to reveal detailed insights into their functional contributions to: a) translation and b) telomere biology. The proposed programme constitutes an integrated, interdisciplinary approach that combines chemical biology, synthetic chemistry, molecular and cell biology together with genomics.'