VPHOP
Osteoporotic Virtual Physiological Human
| Coordinatore | ISTITUTO ORTOPEDICO RIZZOLI
Organization address
address: VIA DI BARBIANO 1/10 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 12˙287˙276 € |
| EC contributo | 9˙184˙863 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2007-2 |
| Funding Scheme | CP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-09-01 - 2012-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ISTITUTO ORTOPEDICO RIZZOLI
Organization address
address: VIA DI BARBIANO 1/10 contact info |
IT (BOLOGNA) | coordinator | 0.00 |
| 2 |
ANSYS FRANCE SAS
Organization address
address: PLACE CHARLES DE GAULLE contact info |
FR (MONTIGNY LE BRETONNEUX) | participant | 0.00 |
| 3 |
ARTS ASSOCIATION
Organization address
address: BOULEVARD DE L' HOPITAL contact info |
FR (PARIS 13) | participant | 0.00 |
| 4 |
BRAINLAB AG
Organization address
address: KAPELLENSTRASSE 12 contact info |
DE (FELDKIRCHEN) | participant | 0.00 |
| 5 |
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Organization address
address: Chariteplatz 1 contact info |
DE (BERLIN) | participant | 0.00 |
| 6 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse contact info |
CH (ZUERICH) | participant | 0.00 |
| 7 |
EMPIRICA GESELLSCHAFT FUER KOMMUNIKATIONS- UND TECHNOLOGIE FORSCHUNG MBH
Organization address
address: OXFORDSTRASSE contact info |
DE (BONN) | participant | 0.00 |
| 8 |
EOS IMAGING SA
Organization address
address: RUE MERCOEUR contact info |
FR (PARIS) | participant | 0.00 |
| 9 |
HASKOLI ISLANDS
Organization address
address: Sudurgata contact info |
IS (REYKJAVIK) | participant | 0.00 |
| 10 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 0.00 |
| 11 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt contact info |
BE (LEUVEN) | participant | 0.00 |
| 12 |
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Organization address
address: VEENPLUIS 4-6 contact info |
NL (BEST) | participant | 0.00 |
| 13 |
SCS SRL
Organization address
address: VIALE FERDINANDO DI SAVOIA 5 contact info |
IT (MILANO) | participant | 0.00 |
| 14 |
SYLVIA LAWRY CENTRE FOR MULTIPLE SCLEROSIS RESEARCH E.V.
Organization address
address: HOHENLINDENER STRASSE 1 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 15 |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address
address: DEN DOLECH contact info |
NL (EINDHOVEN) | participant | 0.00 |
| 16 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 0.00 |
| 17 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse contact info |
CH (BERN) | participant | 0.00 |
| 18 |
UNIVERSITE DE GENEVE
Organization address
address: Rue du General Dufour contact info |
CH (GENEVE) | participant | 0.00 |
| 19 |
UNIVERSITY OF BEDFORDSHIRE
Organization address
address: PARK SQUARE contact info |
UK (LUTON) | participant | 0.00 |
| 20 |
UPPSALA UNIVERSITET
Organization address
address: St Olofsgatan contact info |
SE (UPPSALA) | participant | 0.00 |
| 21 |
ZAPADOCESKA UNIVERZITA V PLZNI
Organization address
address: UNIVERZITNI contact info |
CZ (PILSEN) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determinants but also the neuromuscular condition. The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any prediction based on external and indirect determinants, as it is current clinical practice. These predictions will be used to: i) improve the diagnostic accuracy of the current clinical standards; ii) to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton. For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure. The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations.