DEVANI
Design of a vaccine to immunize neonates against GBS infections through a durable maternal immune response
| Coordinatore | GLAXOSMITHKLINE VACCINES SRL
Organization address
address: Via Fiorentina 1 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 5˙923˙577 € |
| EC contributo | 4˙196˙460 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-01-01 - 2011-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
GLAXOSMITHKLINE VACCINES SRL
Organization address
address: Via Fiorentina 1 contact info |
IT (SIENA) | coordinator | 0.00 |
| 2 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade 1 contact info |
DK (AARHUS C) | participant | 0.00 |
| 3 |
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Organization address
address: VIA FIORENTINA 151 contact info |
IT (SIENA) | participant | 0.00 |
| 4 |
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Organization address
address: Sart Tilman B35 contact info |
BE (LIEGE) | participant | 0.00 |
| 5 |
HEALTH PROTECTION AGENCY HPA
Organization address
address: Central Office - 7th Floor, Holborn Gate - High Holborn 330 contact info |
UK (LONDON) | participant | 0.00 |
| 6 |
ISTITUTO SUPERIORE DI SANITA
Organization address
address: Viale Regina Elena 299 contact info |
IT (ROMA) | participant | 0.00 |
| 7 |
NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES
Organization address
address: blvd. Yanko Sakazov 26 contact info |
BG (SOFIA) | participant | 0.00 |
| 8 |
Servicio Andaluz de Salud
Organization address
address: AVENIDA DE LA CONSTITUCION 18 contact info |
ES (SEVILLA) | participant | 0.00 |
| 9 |
STATNI ZDRAVOTNI USTAV
Organization address
address: Srobarova 48 contact info |
CZ (PRAHA 10) | participant | 0.00 |
| 10 |
UNIVERSITAETSKLINIKUM FREIBURG
Organization address
address: HUGSTETTER STRASSE 49 contact info |
DE (FREIBURG) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Direct vaccination cannot prevent diseases that affect neonates in the first days of life. Group B Streptococcus (GBS) is the major cause of neonatal septicemia and meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of disease in neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses against GBS in women in order to fill this gap in early infancy when direct immunization is not possible. Starting with the genome sequence of 8 strains of GBS, Novartis scientists have identified three proteins that confer protection against lethal challenge in neonatal mice from immunized females. Combinations of CPS conjugates plus the recombinant proteins conferred protection against 12 of 12 GBS strains representing the major disease causing serotypes. In order to translate this research into a viable vaccine it will be necessary to identify appropriate adjuvant and delivery systems capable of inducing a protective response which will last through pregnancy. In order to select the serotypes of CPS to include in the vaccine, it will be necessary to understand the serotype distribution of GBS disease in Europe. Furthermore, an immune surrogate of protection will be required to replace efficacy trials. This proposal will address these issues by evaluating adjuvant and delivery in mouse models of disease and by analysis of maternal antibody levels and strain characteristics in cases versus controls obtained from several countries in Europe'
Introduzione (Teaser)
The idea of immunising women to deliver protective antibodies to their babies is gaining ground in the fight against many diseases. The goal of the DEVANI initiative was to utilise this approach for vaccinating against Group B Streptococcus (GBS) to promote protection in newborns.