DIVA

Genetic DIversity of AVIdins for Novel Biotech Applications

Coordinatore	UNIVERSITAET BASEL    more  Organization address address: Petersplatz 1 city: BASEL postcode: 4003 contact info Titolo: Prof. Nome: Thomas Cognome: Ward Email: send email Telefono: +41 61 267 10 004 Fax: +41 61 267 10 05
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ERG-2008
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-01   -   2011-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET BASEL  Organization address address: Petersplatz 1 city: BASEL postcode: 4003 contact info Titolo: Prof. Nome: Thomas Cognome: Ward Email: send email Telefono: +41 61 267 10 004 Fax: +41 61 267 10 05	CH (BASEL)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Avidins are amongst the most widely used proteins in biotechnology, with applications encompassing molecular labelling, purification & detection, as well as uses in diagnostics, targeted drug delivery and nanotechnology, such as enantioselective catalysis by artificial catalysts. Avidins also serve as outstanding model systems for our understanding of biomolecular interactions, through their extremely high affinity for biotin (dissociation constant, Kd≈10−14–10−16 M).and biotinylated molecules. However, despite their importance in biotechnology, only two avidins have found widespread and routine use amongst the scientific community: chicken avidin and bacterial streptavidin. DIVA aims to exploit the recent identification of novel avidins in DNA sequence databases to generate novel variants of these proteins. DIVA will also use protein engineering to provide further genetic diversity, such as defined asymmetric tetramers of avidins consisting of different subunits. The overall aim is to expand the range of avidins available to biotechnologists and to increase their use and potential applications.'