CHAGASEPINET
Comparative epidemiology of genetic lineages of Trypanosoma cruzi
| Coordinatore | LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Organization address
address: KEPPEL STREET contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 3˙754˙260 € |
| EC contributo | 2˙876˙507 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-B |
| Funding Scheme | CP-SICA |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-01-01 - 2012-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Organization address
address: KEPPEL STREET contact info |
UK (LONDON) | coordinator | 529˙187.00 |
| 2 |
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Organization address
address: Nationalestraat 155 contact info |
BE (ANTWERPEN) | participant | 307˙800.00 |
| 3 |
UNIVERSITE LIBRE DE BRUXELLES
Organization address
address: Avenue Franklin Roosevelt 50 contact info |
BE (BRUXELLES) | participant | 212˙400.00 |
| 4 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 210˙600.00 |
| 5 |
UNIVERSIDAD CENTRAL DE VENEZUELA
Organization address
address: CENT COM LOS CHAGUARAMOS 6/10 contact info |
VE (CARACAS) | participant | 208˙440.00 |
| 6 |
UNIVERSIDAD AUTONOMA DE MADRID
Organization address
address: CALLE EINSTEIN, CIUDAD UNIV CANTOBLANCO RECTORADO 3 contact info |
ES (MADRID) | participant | 200˙160.00 |
| 7 |
UNIVERSITY OF EAST ANGLIA
Organization address
address: EARLHAM ROAD contact info |
UK (NORWICH) | participant | 200˙160.00 |
| 8 |
UNIVERSIDAD MAYOR DE SAN SIMON
Organization address
address: AV. BALLIVIAN ESQUINA REZA 591 contact info |
BO (COCHABAMBA) | participant | 197˙400.00 |
| 9 |
UNIVERSIDAD NACIONAL DE SALTA
Organization address
address: AV BOLIVIA 5150 contact info |
AR (SALTA) | participant | 178˙800.00 |
| 10 |
PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR
Organization address
address: Avenida 12 de Octubre y Carrion contact info |
EC (QUITO) | participant | 148˙800.00 |
| 11 |
FUNDACAO OSWALDO CRUZ
Organization address
address: AVENIDA BRASIL 4365 contact info |
BR (RIO DE JANEIRO) | participant | 146˙400.00 |
| 12 |
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
Organization address
address: Boulevard de Dunkerque - CS 90009 44 contact info |
FR (MARSEILLE) | participant | 117˙960.00 |
| 13 |
UNIVERSIDAD DE LOS ANDES
Organization address
address: CARRERA 1 18A-10 contact info |
CO (BOGOTA DC) | participant | 90˙000.00 |
| 14 |
UNIVERSIDADE FEDERAL DE GOIAS
Organization address
address: CAMPUS SAMAMBAIA contact info |
BR (GOIANIA) | participant | 72˙000.00 |
| 15 |
UNIVERSIDAD DE CHILE
Organization address
address: Av. Libertador Bernardo O'Higgins 1058 contact info |
CL (SANTIAGO) | participant | 56˙400.00 |
Mappa
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Obiettivo del progetto (Objective)
'The focus of this multidisciplinary proposal is to elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. The project will unite skills in genotyping, genomics, genetics and pathogenesis in Europe with considerable compatible skills in South America, and with key research in endemic areas that have distinct characteristics. The proposal is intended to be high impact in terms of both research progress and fostering of collaborative networks. Aim: Elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. Technology development: 1. Develop further and apply MLST; PCR-RFLP and MLMT to the analysis of genetic populations of T. cruzi, 2. Sequence the unresolved genome of T. cruzi I, 3. Develop lineage specific diagnosis, 4. Develop an oligochromatography PCR-dipstick procedure for detection of T. cruzi. Molecular epidemiology: 5. Pilot studies of association between genetic lineage, clinical outcome, and prevalence of congenital infection, 6. Map the silvatic vector, silvatic mammal, human and ecological associations of the T. cruzi genotypes IId,e,b,a. 7. Compare lineage specific pathogenesis and transmissibility of congenital infection in a mouse model, and compare lineage susceptibility to drugs in vitro. Population genetics and phylogenetics: 8. Re-evaluate the population genetics and evolution of T. cruzi lineages. International cryobank and database: 9. Establish in South America an accessible, expanded, international cryobank for T. cruzi, 10. Establish a website and database for outputs of the project. The project encompasses the desirable characteristics prescribed by the call, in that they include: genomics/proteomics; effective, innovative relevance to disease, pathogenesis, drugs, interventions; an integrated multidisciplinarity, and capacity building, networking and training in endemic regions.'
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