CHEARTED

Gene- Environment Interactions in Heart Development

Coordinatore	Academisch Medisch Centrum bij de Universiteit van Amsterdam    more  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Titolo: Dr. Nome: Ruth Cognome: Van Der Gaag Email: send email Telefono: -5664636 Fax: -6976228
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.chearted.eu/
Totale costo	3˙943˙826 €
EC contributo	2˙689˙903 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Academisch Medisch Centrum bij de Universiteit van Amsterdam  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Titolo: Dr. Nome: Ruth Cognome: Van Der Gaag Email: send email Telefono: -5664636 Fax: -6976228	NL (AMSTERDAM)	coordinator	940˙600.00
2	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES  Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Ms. Nome: Elizabeth Cognome: May Email: send email Telefono: 33160878404 Fax: 33160878485	FR (PARIS 15)	participant	840˙500.00
3	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Ms. Nome: Maria Cognome: Vereeken Email: send email Telefono: 3216326504 Fax: 3216326515	BE (LEUVEN)	participant	481˙000.00
4	UNIVERSITY OF NEWCASTLE UPON TYNE  Organization address address: Kensington Terrace 6 city: NEWCASTLE UPON TYNE postcode: NE1 7RU contact info Titolo: Dr. Nome: Amanda Cognome: Gregory Email: send email Telefono: 441913000000 Fax: 441913000000	UK (NEWCASTLE UPON TYNE)	participant	287˙403.00
5	UNIVERSITETET I BERGEN  Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Ms. Nome: Inger Cognome: Gjesdahl Email: send email Telefono: 4755584980 Fax: 4755584991	NO (BERGEN)	participant	74˙400.00
6	UNIVERSITAIR MEDISCH CENTRUM UTRECHT  Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Prof. Nome: Gerard Cognome: Visser Email: send email Telefono: 31887556426 Fax: 31887555320	NL (UTRECHT)	participant	45˙000.00
7	FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG  Organization address address: SCHLOSSPLATZ 4 city: ERLANGEN postcode: 91054 contact info Titolo: Mr. Nome: Ulrich Cognome: Winderl Email: send email Telefono: +49 9131 852 4043 Fax: +49 9131 852 6239	DE (ERLANGEN)	participant	12˙000.00
8	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Michele Cognome: Marron Email: send email Telefono: 442088000000 Fax: 4420890000000	UK (SWINDON)	participant	9˙000.00
9	NEDERLANDSE HARTSTICHTING  Organization address address: Bordewijklaan 3 city: S GRAVENHAGE postcode: 2591 XR contact info Titolo: Ms. Nome: Carla Cognome: Berkman Email: send email Telefono: +3170315 5567 Fax: +3170335 2826	NL (S GRAVENHAGE)	participant	0.00
10	THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN  Organization address address: CORNER HAWKESBURY ROAD AND city: WESTMEAD SYDNEY postcode: 2145 contact info Titolo: Ms. Nome: Wendy Cognome: Haig Email: send email Telefono: +61 2 9845 3653 Fax: +61 2 9845 3845	AU (WESTMEAD SYDNEY)	participant	0.00
11	VICTOR CHANG CARDIAC RESEARCH INSTITUTE LIMITED LBG  Organization address address: LIVERPOOL STREET 405 city: DARLINGHURST postcode: 2010 contact info Titolo: Prof. Nome: Richard Cognome: Harvey Email: send email Telefono: +6129295 8520 Fax: +6129295 8528	AU (DARLINGHURST)	participant	0.00

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 Obiettivo del progetto (Objective)

'Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM incidence. Epidemiological studies have shown that the stress of maternal hypo or hyperglycaemia increases the incidence of CVM. We plan a genetic association study in individuals with and without CVM born to diabetic mothers, to test whether genetic variants are associated with CVM. A similar study, without prior risk hypothesis, addresses tetralogy of Fallot, a CVM, which requires surgery in early life. These studies will reveal common genetic variants associated with CVM and thus add to existing knowledge on the aetiology of CVM. Moreover, the identification of genetic factors that differ in the context of maternal diabetes will disclose any associations in genetic pathways influenced by environmental factors. RNA expression studies in the mouse to identify new genes and pathways involved in outflow tract malformations and maternal diabetes associated with CVM, will complement the human studies. Finally, we will develop a 3D atlas of gene expression patterns and cardiac morphology at key developmental stages that will serve as a morphological framework. Central to our proposal is the development of a bioinformatics tool complemented by an open-access Wiki-based database. The bioinformatics tool will combine the sequence data and expression data generated by the human and mouse studies with morphology and literature to prioritize genes and generate hypotheses. The Wiki, which will contain existing and new genetic and environmental knowledge on heart development, will be an aid for many groups working on cardiovascular development and a novel means of disseminating our findings'