HSP AXONS DROSOPHILA

Role of spastic paraplegia genes and BMP signaling in regulating axonal microtubules and transport

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Barker Email: send email Telefono: -334722 Fax: -334167
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	168˙256 €
EC contributo	168˙256 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2011-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Barker Email: send email Telefono: -334722 Fax: -334167	UK (CAMBRIDGE)	coordinator	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'The hereditary spastic paraplegias (HSPs) are a set of diseases in which longer spinal cord axons degenerate. The pathological mechanisms of degeneration in HSPs are poorly understood, even in cases when causative genes have been cloned. To date, some thirty causative loci (SPG loci) have been mapped and thirteen cloned. The host laboratory has recently identified a mechanism by which one gene product, SPG6, can affect axonal transport. The Drosophila SPG6 homolog, spichthyin, is a novel antagonist of BMP/TGF-beta signaling that acts by modulating receptor traffic. Furthermore, the host lab has found that BMP signaling is required for maintenance of axonal microtubules (MTs) in Drosophila, and that impairment of this signaling leads to loss of axonal MTs and impairment of axonal transport. This role of BMP signaling is a novel cellular process, and may be a target for other degenerative diseases. The purpose of the project is to determine how BMP signaling regulates axonal MTs. The specific objectives are (i) to determine if BMP regulation of MTs acts via the canonical BMP pathway that involves transcriptional regulation, and/or via a more localised non-canonical pathway; (ii) to test if the MT regulation occurs by regulation of tubulin expression, and/or by activity of of MT-binding proteins; (iii) to use live imaging and techniques such as FRAP to study the effect of BMP signaling on dynamic localization and traffic of MTs. The identification of such mechanisms will allow a better understanding of both BMP signaling and MT regulation in both healthy and disease states. This project is original and innovative in that it builds on recent pioneering work in the host lab that links an important neuronal signaling pathway with basic processes of axonal MT regulation and transport. Study of the target pathway of SPG6 is timely because it can provide a framework of knowledge to understand the mechanisms of degeneration in other axonal degeneration diseases.'