NANOMMUNE
Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system
| Coordinatore | KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
| Nazionalità Coordinatore | Sweden [SE] |
| Sito del progetto | http://www.nanommune.eu |
| Totale costo | 4˙310˙500 € |
| EC contributo | 3˙358˙500 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2007-SMALL-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-09-01 - 2011-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | coordinator | 0.00 |
| 2 |
EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT
Organization address
address: Ueberlandstrasse 129 contact info |
CH (DUEBENDORF) | participant | 0.00 |
| 3 |
INSTITUTE OF OCCUPATIONAL MEDICINE
Organization address
address: Research Avenue North, Riccarton 45 contact info |
UK (EDINBURGH) | participant | 0.00 |
| 4 |
KUNGLIGA TEKNISKA HOEGSKOLAN
Organization address
address: Valhallavaegen 79 contact info |
SE (STOCKHOLM) | participant | 0.00 |
| 5 |
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH
Organization address
address: WILLOWDALE ROAD MS L 2015 contact info |
US (MORGANTOWN) | participant | 0.00 |
| 6 |
North Carolina State University
Organization address
address: SULLIVAN DRIVE 270 contact info |
US (RALEIGH) | participant | 0.00 |
| 7 |
TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
FI (TURUN YLIOPISTO) | participant | 0.00 |
| 8 |
UNIVERSITAET ZU KOELN
Organization address
address: ALBERTUS MAGNUS PLATZ contact info |
DE (KOELN) | participant | 0.00 |
| 9 |
UNIVERSITY OF PITTSBURGH
Organization address
address: WESLEY W POSVAR HALL 4E contact info |
US (PITTSBURGH) | participant | 0.00 |
| 10 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immune-competent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall, the results generated through this international program will contribute to the understanding and mitigation of possible adverse effects of nanomaterials.'
Introduzione (Teaser)
Engineered nanomaterials have the potential to improve many aspects of modern day living. However, more knowledge is needed regarding potential hazards to human health.
Descrizione progetto (Article)
The 'Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system' (Nanommune) project is assessing the potential of engineered nanomaterials (ENs) to adversely affect the human immune system. The 3-year project brings together 10 partner institutes in the EU and the United States focusing on procurement, synthesis and detailed physicochemical characterisation of various EN categories.
The immune system is designed to respond to threats in the form of pathogens or foreign agents. With this in mind, Nanommune is working to show that recognition or non-recognition of ENs by immune-competent cells is a determining factor in their distribution and harmful effects.
A multidisciplinary approach is in place to monitor these potential hazards and determine nanotoxic profiles of ENs. The end goal is to create a base of read-out systems for predicting the toxic potential of ENs.
To date, a management office has been set up and a project website launched. Kick-off and consortium meetings have also been held. Various articles have been published, including one review in the Annual Review of Pharmacology and Toxicology.
In the first 18 months, and after establishing various standard operating procedures (SOPs), activities concentrated on material synthesis and characterisation and in vitro assessments of ENs. So far, researchers have studied the nanomaterials of 15 systems, allowing partner institutions to make good progress in enhancing knowledge of how macrophages can be alerted to or recognise nanomaterials. Macrophages act as sensors that detect a threat and initiate a relevant immune response such as inflammation or elimination.
Results from one set of studies show promise for having carbon nanotubes actually degrade in the biological environment. The scientists also showed that nanotubes are recognisable by macrophages. Other studies have made headway regarding the development of materials for drug delivery and other biomedical applications.
The Nanommune project's goal of elucidating the hazardous effects of ENs on the immune system will ultimately deliver reliable and sound assessments of the risks to human health that these materials pose. Results are set to benefit public health, researchers and industry.