MALSIG
Signalling in life cycle stages of malaria parasites
| Coordinatore |
Organization address
address: 101 Rue de Tolbiac contact info |
| Nazionalità Coordinatore | Non specificata |
| Totale costo | 4˙078˙878 € |
| EC contributo | 3˙000˙000 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-200 |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-02-01 - 2012-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | coordinator | 472˙000.00 |
| 2 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 332˙000.00 |
| 3 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 332˙000.00 |
| 4 |
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Organization address
address: PADRICIANO 99 contact info |
IT (TRIESTE) | participant | 180˙000.00 |
| 5 |
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Organization address
address: BERNHARD NOCHT STRASSE 74 contact info |
DE (HAMBURG) | participant | 166˙000.00 |
| 6 |
GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
UK (LONDON) | participant | 166˙000.00 |
| 7 |
ISTITUTO SUPERIORE DI SANITA
Organization address
address: Viale Regina Elena 299 contact info |
IT (ROMA) | participant | 166˙000.00 |
| 8 |
JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG
Organization address
address: SANDERRING 2 contact info |
DE (WUERZBURG) | participant | 166˙000.00 |
| 9 |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Organization address
address: KEPPEL STREET contact info |
UK (LONDON) | participant | 166˙000.00 |
| 10 |
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Organization address
address: Cranmer Terrace contact info |
UK (LONDON) | participant | 166˙000.00 |
| 11 |
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Organization address
address: LANGE KLEIWEG 161 contact info |
NL (RIJSWIJK ZH) | participant | 166˙000.00 |
| 12 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 166˙000.00 |
| 13 |
INDIAN INSTITUTE OF SCIENCE
Organization address
address: CROSS MALLESHWARAM 18 contact info |
IN (BANGALORE) | participant | 90˙000.00 |
| 14 |
JAWAHARLAL NEHRU UNIVERSITY
Organization address
address: New Mehrouli Road contact info |
IN (NEW DELHI) | participant | 90˙000.00 |
| 15 |
NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY
Organization address
address: ARUNA ASAF ALI MARG contact info |
IN (NEW DELHI) | participant | 90˙000.00 |
| 16 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 86˙000.00 |
| 17 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic.'
Introduzione (Teaser)
European and Indian researchers teamed up to study the signalling pathways necessary for the survival and transmission of the malaria-causing parasite (Plasmodium falciparum). Some of the molecules detected could potentially serve as future targets for therapeutic intervention.
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