PROMOTE

The molecular mechanism of the reversible switch between cell proliferation and migration. The regulatory function of the ERK pathway and ERK pathway scaffold RACK1

Coordinatore	"MIKROBIOLOGICKY USTAV - AVCR, V.V.I."    more  Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 14220 contact info Titolo: Dr. Nome: Ondrej Cognome: Schröffel Email: send email Telefono: -96441923 Fax: -44471853
Nazionalità Coordinatore	Czech Republic [CZ]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IRG-2008
Funding Scheme	MC-IRG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2013-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	"MIKROBIOLOGICKY USTAV - AVCR, V.V.I."  Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 14220 contact info Titolo: Dr. Nome: Ondrej Cognome: Schröffel Email: send email Telefono: -96441923 Fax: -44471853	CZ (PRAHA 4)	coordinator	100˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Recent studies suggest that the microenvironment surrounding primary tumor cells can temporarily change tumor cell gene expression, resulting in suppressed cell proliferation and increased cell motility. This genetic program allows tumor cells to invade the surrounding tissue, metastasize to distant parts of the body and suppress apoptosis induced by changes in the environment. Once cells reach a favorable milieu, they suppress migration, reactivate the proliferation program and expand in the target organ. Although many components involved in this switch between proliferative and migratory phenotypes have been identified, the precise molecular mechanism remains unknown. One of the protein shown to be specifically overexpresed in migratory but not in proliferating cells is adaptor/scaffold protein RACK1. We recently identified RACK1 as a scaffold-like protein in the ERK pathway which controls ERK activation and targets active ERK to specific intracellular compartments. My preliminary evidence indicates that the expression level of RACK1 correlates with the cell's ability to either migrate or proliferate. Thus, RACK1 may serve as a key molecular “switch” that controls whether ERK signaling regulates the proliferative or the migratory program. The goal of this research proposal is to understand how RACK1 and the ERK pathway regulate the switch between proliferative and migratory phenotypes and the contribution this “migratory switch” has on the development and progression of colorectal cancer.'