HYDROXCAT

Novel catalytic reactions involving O-H bonds

Coordinatore	WEIZMANN INSTITUTE OF SCIENCE    more  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: +972 8 934 4026 Fax: +972 8934 4165
Nazionalità Coordinatore	Israel [IL]
Totale costo	0 €
EC contributo	172˙969 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IIF-2008
Funding Scheme	MC-IIF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-04-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: +972 8 934 4026 Fax: +972 8934 4165	IL (REHOVOT)	coordinator	172˙969.90

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 Obiettivo del progetto (Objective)

'Our group has recently discovered novel reactions catalyzed by pyridine-based pincer complexes of ruthenium, including dehydrogenation of alcohols to form esters and H2, hydrogenation of esters to alcohols under mild conditions and an unprecedented amide synthesis: catalytic coupling of amines with alcohols, with liberation of H2 (Science, 2007, 317, 790; C&EN Aug 13, 2007, p. 10). The reactions are very efficient, proceed under neutral conditions and produce no waste. Our studies indicate that these reactions involve unprecedented cooperation between the metal and ligand by an aromatization-dearomatization of the pyridine core of the pincer system. We plan to (a) study the mechanism of the O-H activation step of alcohols by dearomatized PNP and PNN Ru complexes (d) develop mechanistic understanding of catalytic alcohol dehydrogenation to esters and catalytic amidation of alcohols with amines, and design superior pyridine-based pincer ligands for these reactions (e) prepare analogous iron complexes and study their reactivity and catalytic activity (f) develop new catalytic reactions based on alcohols, including dehydrogenative coupling reactions of aldehydes with alcohols, and aldehydes with amines, to form esters and amides, respectively, and anti-Markovnikov addition of water and to alkenes. This research is expected to lead to fundamental understanding of unprecedented organometallic transformations, and to novel, environmentally benign catalytic processes of industrial significance.'