DCN

Dynamic Combinatorial Nanoparticles for Protein Surface Recognition

Coordinatore	RIJKSUNIVERSITEIT GRONINGEN    more  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: Jan Cognome: Poutsma Email: send email Telefono: 31 50 3634142 Fax: 31 50 3634500
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	0 €
EC contributo	169˙992 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IIF-2008
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2011-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: Jan Cognome: Poutsma Email: send email Telefono: 31 50 3634142 Fax: 31 50 3634500	NL (GRONINGEN)	coordinator	169˙992.40

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 Obiettivo del progetto (Objective)

'Recent developments in genomics and proteomics have generated an urgent need for new methods of interrogating and targeting biochemical networks. In particular new means of interfering with protein-protein interactions are in high demand and of considerable therapeutic potential. New materials are needed that can recognise and bind to specific protein surfaces. We aim to develop a new approach to the recognition of proteins using individual nanoparticles and dynamic networks of nanoparticles. This requires the development of: 1. Functional nanoparticles capable of selectively recognising proteins. We will explore the potential of dynamic combinatorial chemistry to direct the functionalisation of the surface of the nanoparticles. 2. A means of translating nanoparticle-protein interactions into a signal. Our approach is to use nanoparticle networks that respond to the presence of proteins with a redistribution of their surface functionalisation, which, in turn, produces an optical readout through fluorescence resonance energy transfer. The project is critically dependent on the host's expertise on dynamic combinatorial chemistry and the applicant's expertise on the characterisation of nanostructures. The expected outcome is a conceptually new means of interfacing functional nanoparticles with biomolecules, based on an innovative molecular network approach. This systems chemistry strategy breaks with the reductionist tradition that has characterised most research in chemistry for the last centuries.'