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CHIBCHA

Genetic study of Common Hereditary Bowel Cancers in Hispania and the Americas

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://www.well.ox.ac.uk/CHIBCHA/
Totale costo	3˙956˙917 €
EC contributo	2˙974˙288 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-SICA
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-06-01 - 2013-05-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	1˙624˙680.40
2	UNIVERSIDADE DE SANTIAGO DE COMPOSTELA Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N" city: SANTIAGO DE COMPOSTELA postcode: 15782 contact info Titolo: Dr. Nome: Fernando Cognome: Sedano Arnaez Email: send email Telefono: +34 981 547050 Fax: +34 981 528019	ES (SANTIAGO DE COMPOSTELA)	participant	540˙800.00
3	Universidad del Tolima Organization address address: Altos de Santa Helena city: Ibague postcode: AA546 contact info Titolo: Dr. Nome: John Jairo Cognome: Mendez Arteaga Email: send email Telefono: +57 8 2669182 Fax: +57 8 2669162	CO (Ibague)	participant	274˙800.00
4	Fundacao Antonio Prudente Organization address address: Rua Professor Antonio Prudente 211 city: Sao Paulo postcode: 1509010 contact info Titolo: Dr. Nome: Benedito Cognome: Rossi Email: send email Telefono: +5511 32070500 Fax: +5511 32070500	BR (Sao Paulo)	participant	165˙600.00
5	Universidad Autonoma de Nuevo Leon Organization address address: Av. Universidad s/n city: San Nicolas de los Garza postcode: 66428 contact info Titolo: Ms. Nome: Nora Luisa Cognome: Salas De La Rosa Email: send email Telefono: +5281 83294032 Fax: +5281 83764071	MX (San Nicolas de los Garza)	participant	165˙600.00
6	UNIVERSIDAD DE LA REPUBLICA Organization address address: Avenida 18 de julio 1824 city: Montevideo postcode: 11200 contact info Titolo: Ms. Nome: Elizabeth Cognome: Prendez Email: send email Telefono: +598 2 4091104 06 Fax: +598 2 4084303	UY (Montevideo)	participant	80˙400.00
7	FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA Organization address address: CARRER ROSSELLO 149-153 city: BARCELONA postcode: 8029 contact info Titolo: Mr. Nome: Emili Cognome: Bargallo Email: send email Telefono: +34 93 2275707 Fax: +34 93 2279205	ES (BARCELONA)	participant	63˙360.00
8	"INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE" Organization address address: RUA ANTONIO BERNARDINO ALMEIDA city: PORTO postcode: 4200-072 contact info Titolo: Dr. Nome: Ana Celeste Cognome: Costa Strecht Monteiro Email: send email Telefono: +351 225084000 Fax: +351 225084001	PT (PORTO)	participant	58˙800.00
9	FUNDACION DE INVESTIGACIONES GENOMICAS Organization address address: YERBAL 2365 PB G-H city: Buenos Aires postcode: C1406GKA contact info Titolo: Mr. Nome: Carlos Diego Cognome: Cid Email: send email Telefono: +5411 48033544 Fax: +5411 4611 4110	AR (Buenos Aires)	participant	247.62
10	KBiosciences ltd Organization address address: Unit 7 Maple Park Essex Road city: Hoddesdon postcode: EN110EX contact info Titolo: Mr. Nome: Philip Cognome: Robinson Email: send email Telefono: +44 1992 470757 Fax: +44 8700 511302	UK (Hoddesdon)	participant	0.00

Mappa

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cancer disease risk shown crc snps detect genes controls la population q variants populations

Obiettivo del progetto (Objective)

'Colorectal cancer (CRC) is common in both sexes, has relatively poor outcome and has no major avoidable risk factor. Recent studies have shown that common inherited single nucleotide polymorphisms (SNPs) can increase cancer risk. We have shown CRC risk to be associated with SNPs on chromosomes 8q24.21, 15q14 and 8q21. These variants account for <5% of the genetic risk of CRC, but will be very important when their effects are added to those of other, as-yet undetected CRC SNPs. A few genome-wide association studies (GWASs) based on populations of European descent are trying to identify the remaining common CRC genes. Evidence suggests that these studies will not be large enough on their own to detect all CRC SNPs, as: relative risks associated with most SNPs are modest; some disease alleles are rare, at least in Europe; and many variants may lie outside conventional gene boundaries or haplotype blocks. The admixed LA population provides an exciting opportunity to identify new CRC genes that are more tractable to detection in LA, or have been missed by chance in European studies. We shall undertake a combined GWAS and admixture mapping study for CRC predisposition genes in 6,000 LA cases and 6,000 controls. We shall test the disease-associated variants in 3,500 cases and 3,500 controls from Europe. We aim primarily to detect SNPs with effects in both LA and Europe, but also SNPs with effects specific to LA. Eventually, we aim to develop a polymorphism panel for predicting the risk of CRC in the general population, so that those at increased risk can be offered effective measures to prevent cancer. CRC is increasing in frequency in LA and prognosis is poorer than in Europe. We shall use our project as a focus for education about CRC, especially in LA. The study will also provide training for young LA researchers. Our work will provide a direct benefit to medical science and the populations of LA and Europe.'